Clear Cell Carcinomas of the Ovary: A Multi-Institutional Study of 129 Cases in Korea With Prognostic Significance of Emi1 and Galectin-3
- Authors
- Min, Kyueng-Whan; Park, Moon Hyang; Hong, Sung Ran; Lee, Heejung; Kwon, Sun Young; Hong, Sook Hee; Joo, Hee Jae; Park, In Ae; An, Hee Jung; Suh, Kwang Sun; Oh, Hoon Kyu; Yoo, Chong Woo; Kim, Mi Jin; Chang, Hee Kyung; Jun, Sun Young; Yoon, Hye Kyoung; Chang, Eun Deok; Kim, Dong Won; Kim, Insun
- Issue Date
- 1월-2013
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- Clear cell carcinoma; Emi1 protein; Galectin-3; p53 antigen; Ki-67 antigen; Ovarian cancer
- Citation
- INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, v.32, no.1, pp.3 - 14
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
- Volume
- 32
- Number
- 1
- Start Page
- 3
- End Page
- 14
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104337
- DOI
- 10.1097/PGP.0b013e31825554e9
- ISSN
- 0277-1691
- Abstract
- Accurate diagnosis of ovarian clear cell carcinoma (CCC) is important because of its poor prognosis with chemoresistance and a high recurrent rate. The clinicopathologic characteristics and prognostic significance of the cell cycle regulator [ early mitotic inhibitor-1 (Emi1)] and galactoside-binding protein (Galectin-3) were evaluated. Among 155 CCCs from 18 hospitals in Korea between 1995 and 2006, 129 pure CCCs were selected with consensus using immunohistochemical stains for hepatocyte nuclear factor-1 beta, Wilms' tumor protein, and estrogen receptor. The expressions of Emi1, Galectin-3, p53, and Ki-67 labeling index were analyzed with clinicopathologic parameters and the patient's survival. The mean age of the patients was 49.6 yr; the tumors were bilateral in 10.9%, and the average size was 12 cm. Adenofibromatous component was found in 7%, and endometriosis in 48.1% of the cases. Psammoma body was seen in 16.3%. Disease-free survival and overall survival rates were 78.3% and 79.1%, respectively. The International Federation of Obstetrics and Gynecology (FIGO) stage was the most important prognostic indicator. Emi1 expression (>5%) was seen in 23.3% of CCCs, and associated with high FIGO grades and poor overall survival (P<0.05). High Galectin-3 (>= 80%) expression was seen in 59.7% of CCCs, and associated with FIGO stages III and IV, and high Ki-67 labeling index. High Ki-67 labeling index (>= 50%) and p53 expression (>= 50%) were seen in 27.1% and 18.6% of CCCs, respectively, but there was no clinicopathologic and prognostic significance. On the basis of the fact that the expression of Emi1 in CCC was correlated with a high histologic grade and worse overall survival, target therapy using inhibitors of Emi1 may be tried in the management of CCC patients with Emi1 expression.
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