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High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010
- Authors
- Cho, Han-Gil; Choi, Jang-Hoon; Kim, Woon-Ho; Hong, Hae-Kun; Yoon, Mi-Hye; Jho, Eek-Hoon; Kang, Chun; Lim, Young-Hee
- Issue Date
- 1월-2013
- Publisher
- SPRINGER WIEN
- Keywords
- Influenza A virus; Amantadine resistance; Phylogenetic analysis
- Citation
- ARCHIVES OF VIROLOGY, v.158, no.1, pp.241 - 245
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARCHIVES OF VIROLOGY
- Volume
- 158
- Number
- 1
- Start Page
- 241
- End Page
- 245
- ISSN
- 0304-8608
- Abstract
- Amantadine resistance among influenza A viruses was investigated in South Korea in 2005-2010. Of 308 influenza A viruses examined, 229 had the S31N substitution in the M2 protein. The frequency of amantadine resistance was 30 %, 100 %, and 76 % in influenza A/H1N1, pandemic A/H1N1 2009(A/H1N1pdm), and A/H3N2 subtypes, respectively. The amantadine-resistant influenza A/H1N1pdm and A/H3N2 viruses were circulating continuously from 2008 to 2009 and from 2005 to 2006, respectively. Amantadine resistance among influenza A viruses increased dramatically during the 5-year study period, and this has diminished the usefulness of this class of drugs.
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