Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and Type 1 diabetes
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T05:53:20Z | - |
dc.date.available | 2021-09-06T05:53:20Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104380 | - |
dc.description.abstract | The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8 %) and 774 (38.2 %), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95 % CI 1.421, 1.827, p < 1 x 10(-8)) without between-study heterogeneity (I-2 = 32.5, p = 0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values = 0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95 % CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | SINGLE NUCLEOTIDE POLYMORPHISM | - |
dc.subject | LYMPHOID TYROSINE PHOSPHATASE | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | AUTOIMMUNE-DISEASES | - |
dc.subject | FUNCTIONAL VARIANT | - |
dc.subject | GENE | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | TRIALS | - |
dc.subject | LOCUS | - |
dc.subject | BIAS | - |
dc.title | Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and Type 1 diabetes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s11033-012-2051-8 | - |
dc.identifier.scopusid | 2-s2.0-84871309395 | - |
dc.identifier.wosid | 000312435500025 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.40, no.1, pp.211 - 215 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 40 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 215 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | SINGLE NUCLEOTIDE POLYMORPHISM | - |
dc.subject.keywordPlus | LYMPHOID TYROSINE PHOSPHATASE | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASES | - |
dc.subject.keywordPlus | FUNCTIONAL VARIANT | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | TRIALS | - |
dc.subject.keywordPlus | LOCUS | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | Protein tyrosine phosphatase nonreceptor 22 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Type 1 diabetes | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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