Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and Type 1 diabetes
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- 1월-2013
- Publisher
- SPRINGER
- Keywords
- Protein tyrosine phosphatase nonreceptor 22; Polymorphism; Type 1 diabetes; Meta-analysis
- Citation
- MOLECULAR BIOLOGY REPORTS, v.40, no.1, pp.211 - 215
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BIOLOGY REPORTS
- Volume
- 40
- Number
- 1
- Start Page
- 211
- End Page
- 215
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104380
- DOI
- 10.1007/s11033-012-2051-8
- ISSN
- 0301-4851
- Abstract
- The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8 %) and 774 (38.2 %), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95 % CI 1.421, 1.827, p < 1 x 10(-8)) without between-study heterogeneity (I-2 = 32.5, p = 0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values = 0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95 % CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.
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