Cocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus Accumbens
DC Field | Value | Language |
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dc.contributor.author | 정은솔 | - |
dc.contributor.author | 이효진 | - |
dc.contributor.author | 심혜리 | - |
dc.contributor.author | 백자현 | - |
dc.date.accessioned | 2021-09-06T06:50:52Z | - |
dc.date.available | 2021-09-06T06:50:52Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104766 | - |
dc.description.abstract | To determine the role of dopamine D2 receptor (D2R) in the nucleus accumbens (NAc) core in cocaine-induced behavioral sensitization, D2R antagonist, raclopride was bilaterally microinjected (2.5 or 5 nmol) into the NAc core of WT and D2R-/- mice and the initiation and expression phase of cocaine-mediated locomotor sensitization were analyzed. WT and D2R knockout (D2R-/-) mice received bilateral injections of either saline, or raclopride at the NAc core 30 min before each of five daily repeated injections of saline or cocaine (15 mg/kg i.p.). Following 2 weeks of withdrawal after repeated exposure to cocaine, the animals were pre-treated with an intra-accumbal injection of vehicle or raclopride before receiving a systemic cocaine challenge for the expression of sensitization. Animals which had been microinjected raclopride into NAc core displayed the enhancement of cocaine-induced behavioral response for the initiation but also for the expression of sensitization in WT as well as in D2R-/- mice, which was thus unaltered as compared to vehicle-injected control group. These results suggest that D2R in NAc core is not involved in cocaine-induced behavioral sensitization. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Cocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus Accumbens | - |
dc.title.alternative | Cocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus Accumbens | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 백자현 | - |
dc.identifier.bibliographicCitation | Experimental Neurobiology, v.22, no.3, pp.224 - 231 | - |
dc.relation.isPartOf | Experimental Neurobiology | - |
dc.citation.title | Experimental Neurobiology | - |
dc.citation.volume | 22 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 224 | - |
dc.citation.endPage | 231 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001811598 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordAuthor | dopamine receptor | - |
dc.subject.keywordAuthor | nucleus accumbens | - |
dc.subject.keywordAuthor | cocaine | - |
dc.subject.keywordAuthor | addiction | - |
dc.subject.keywordAuthor | behavioral sensitization | - |
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