Cocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus AccumbensCocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus Accumbens
- Other Titles
- Cocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus Accumbens
- Authors
- 정은솔; 이효진; 심혜리; 백자현
- Issue Date
- 2013
- Publisher
- 한국뇌신경과학회
- Keywords
- dopamine receptor; nucleus accumbens; cocaine; addiction; behavioral sensitization
- Citation
- Experimental Neurobiology, v.22, no.3, pp.224 - 231
- Indexed
- KCI
OTHER
- Journal Title
- Experimental Neurobiology
- Volume
- 22
- Number
- 3
- Start Page
- 224
- End Page
- 231
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104766
- ISSN
- 1226-2560
- Abstract
- To determine the role of dopamine D2 receptor (D2R) in the nucleus accumbens (NAc) core in cocaine-induced behavioral sensitization, D2R antagonist, raclopride was bilaterally microinjected (2.5 or 5 nmol) into the NAc core of WT and D2R-/- mice and the initiation and expression phase of cocaine-mediated locomotor sensitization were analyzed. WT and D2R knockout (D2R-/-) mice received bilateral injections of either saline, or raclopride at the NAc core 30 min before each of five daily repeated injections of saline or cocaine (15 mg/kg i.p.). Following 2 weeks of withdrawal after repeated exposure to cocaine, the animals were pre-treated with an intra-accumbal injection of vehicle or raclopride before receiving a systemic cocaine challenge for the expression of sensitization. Animals which had been microinjected raclopride into NAc core displayed the enhancement of cocaine-induced behavioral response for the initiation but also for the expression of sensitization in WT as well as in D2R-/- mice, which was thus unaltered as compared to vehicle-injected control group. These results suggest that D2R in NAc core is not involved in cocaine-induced behavioral sensitization.
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