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Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dual-optical imaging techniques
- Authors
- Lee, Seungduk; Koh, Dalkwon; Jo, Areum; Lim, Hae Young; Jung, Young-Jin; Kim, Choong-Ki; Seo, Youngwook; Im, Chang-Hwan; Kim, Beop-Min; Suh, Minah
- Issue Date
- 26-3월-2012
- Publisher
- OPTICAL SOC AMER
- Citation
- OPTICS EXPRESS, v.20, no.7, pp.6932 - 6943
- Indexed
- SCIE
SCOPUS
- Journal Title
- OPTICS EXPRESS
- Volume
- 20
- Number
- 7
- Start Page
- 6932
- End Page
- 6943
- ISSN
- 1094-4087
- Abstract
- We studied depth-dependent cerebral hemodynamic responses of rat brain following direct cortical electrical stimulation (DCES) in vivo with optical recording of intrinsic signal (ORIS) and near-infrared spectroscopy (NIRS). ORIS is used to visualize the immediate hemodynamic changes in cortical areas following the stimulation, whereas NIRS measures the hemodynamic changes originating from subcortical areas. We found strong hemodynamic changes in relation to DCES both in ORIS and NIRS data. In particular, the signals originating from cortical areas exhibited a tri-phasic response, whereas those originating from subcortical regions exhibited multi-phasic responses. In addition, NIRS signals from two different sets of source-detector separation were compared and analyzed to investigate the causality of perfusion, which demonstrated downstream propagation, indicating that the upper brain region reacted faster than the deep region. (C) 2012 Optical Society of America
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Collections - Graduate School > Department of Bioengineering > 1. Journal Articles
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