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Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dual-optical imaging techniques

Authors
Lee, SeungdukKoh, DalkwonJo, AreumLim, Hae YoungJung, Young-JinKim, Choong-KiSeo, YoungwookIm, Chang-HwanKim, Beop-MinSuh, Minah
Issue Date
26-3월-2012
Publisher
OPTICAL SOC AMER
Citation
OPTICS EXPRESS, v.20, no.7, pp.6932 - 6943
Indexed
SCIE
SCOPUS
Journal Title
OPTICS EXPRESS
Volume
20
Number
7
Start Page
6932
End Page
6943
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/105280
DOI
10.1364/OE.20.006932
ISSN
1094-4087
Abstract
We studied depth-dependent cerebral hemodynamic responses of rat brain following direct cortical electrical stimulation (DCES) in vivo with optical recording of intrinsic signal (ORIS) and near-infrared spectroscopy (NIRS). ORIS is used to visualize the immediate hemodynamic changes in cortical areas following the stimulation, whereas NIRS measures the hemodynamic changes originating from subcortical areas. We found strong hemodynamic changes in relation to DCES both in ORIS and NIRS data. In particular, the signals originating from cortical areas exhibited a tri-phasic response, whereas those originating from subcortical regions exhibited multi-phasic responses. In addition, NIRS signals from two different sets of source-detector separation were compared and analyzed to investigate the causality of perfusion, which demonstrated downstream propagation, indicating that the upper brain region reacted faster than the deep region. (C) 2012 Optical Society of America
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