Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes
DC Field | Value | Language |
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dc.contributor.author | Hong, Seong Su | - |
dc.contributor.author | Lee, Ji Hae | - |
dc.contributor.author | Jeong, Wonsik | - |
dc.contributor.author | Kim, Nahyun | - |
dc.contributor.author | Jin, Hui Zi | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Lee, Hak-Ju | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.contributor.author | Jang, Dae Sik | - |
dc.contributor.author | Lee, Dongho | - |
dc.date.accessioned | 2021-09-06T08:11:26Z | - |
dc.date.available | 2021-09-06T08:11:26Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2012-03-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105291 | - |
dc.description.abstract | A new acetylenic acid, (10E, 14Z)-9-oxooctadeca-10,14-dien-12-ynoicacid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E, 14Z)-9-hydroxyoctadeca-10,14-dien-12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-gamma with an EC50 value of 1.88 mu M as measured by a reporter gene assay. Expression of PPAR-gamma target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-gamma potential agonist that regulates transcription of the PPAR-gamma target genes. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PPAR | - |
dc.subject | APOPTOSIS | - |
dc.title | Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sung-Joon | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1016/j.bmcl.2012.01.070 | - |
dc.identifier.scopusid | 2-s2.0-84862825156 | - |
dc.identifier.wosid | 000301285500046 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.6, pp.2347 - 2349 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 22 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2347 | - |
dc.citation.endPage | 2349 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | PPAR | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | Chanterelle | - |
dc.subject.keywordAuthor | Cantharellus cibarius | - |
dc.subject.keywordAuthor | Peroxisome proliferator-activated receptor (PPAR)-gamma agonist | - |
dc.subject.keywordAuthor | Acetylenic acid | - |
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