Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans
DC Field | Value | Language |
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dc.contributor.author | Hassen, L. J. | - |
dc.contributor.author | Ueshima, H. | - |
dc.contributor.author | Curb, J. D. | - |
dc.contributor.author | Choo, J. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Masaki, K. | - |
dc.contributor.author | Kadowaki, T. | - |
dc.contributor.author | Shin, C. | - |
dc.contributor.author | Evans, R. W. | - |
dc.contributor.author | Seto, T. B. | - |
dc.contributor.author | Fujiyoshi, A. | - |
dc.contributor.author | Willcox, B. J. | - |
dc.contributor.author | Sutton-Tyrrell, K. | - |
dc.contributor.author | Kadota, A. | - |
dc.contributor.author | El-Saed, A. | - |
dc.contributor.author | Miura, K. | - |
dc.contributor.author | Kuller, L. H. | - |
dc.contributor.author | Sekikawa, A. | - |
dc.date.accessioned | 2021-09-06T08:18:23Z | - |
dc.date.available | 2021-09-06T08:18:23Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0954-3007 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105332 | - |
dc.description.abstract | Background/Objectives: Numerous studies reported beneficial effects of marine n-3 fatty acids (n-3 FAs) on cardiovascular disease (CVD) and its risk factors. However, the association of marine n-3 FAs with plasma fibrinogen, a risk factor for CVD, remains uncertain. Subjects/Methods: In a population-based, cross-sectional study of 795 men aged 40-49 without CVD (262 whites in Allegheny County, Pennsylvania, USA, 302 Japanese in Kusatsu, Japan and 229 Japanese Americans in Honolulu, Hawaii, USA), we examined the association of marine n-3 FAs with plasma fibrinogen. Serum FAs were measured by capillary gas-liquid chromatography. Marine n-3 FAs were defined as the sum of docosahexaenoic, eicosapentaenoic and docosapentaenoic acids. Plasma fibrinogen was measured by an automated clot-rate assay. Multiple linear regression analyses were performed to assess the association. Results: White, Japanese and Japanese-American men had mean marine n-3 FAs levels of 3.47%, 8.78% and 4.46%, respectively. Japanese men had a significant inverse association of marine n-3 FAs with fibrinogen (standardized regression coefficient of -0.11, P=0.049), after adjusting for age, body-mass index and current smoking. The significant inverse association remained after further adjusting for diabetes, C-reactive protein, triglycerides and other variables. White or Japanese-American men did not show a significant association. Conclusions: We observed the significant inverse association of marine n-3 FAs with fibrinogen in Japanese, but not in whites or Japanese Americans. The observation suggests that marine n-3 FAs at very high levels, as seen in the Japanese, may decrease plasma fibrinogen levels. European Journal of Clinical Nutrition (2012) 66, 329-335; doi: 10.1038/ejcn.2011.155; published online 7 September 2011 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CARDIOVASCULAR-DISEASE RISK | - |
dc.subject | FISH-OIL SUPPLEMENTS | - |
dc.subject | CORONARY-HEART-DISEASE | - |
dc.subject | C-REACTIVE PROTEIN | - |
dc.subject | LONG-CHAIN | - |
dc.subject | DIETARY SUPPLEMENTATION | - |
dc.subject | LINOLENIC ACID | - |
dc.subject | UNITED-STATES | - |
dc.subject | WEIGHT-LOSS | - |
dc.subject | MEN | - |
dc.title | Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choo, J. | - |
dc.contributor.affiliatedAuthor | Shin, C. | - |
dc.identifier.doi | 10.1038/ejcn.2011.155 | - |
dc.identifier.scopusid | 2-s2.0-84858079248 | - |
dc.identifier.wosid | 000301382400006 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CLINICAL NUTRITION, v.66, no.3, pp.329 - 335 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CLINICAL NUTRITION | - |
dc.citation.title | EUROPEAN JOURNAL OF CLINICAL NUTRITION | - |
dc.citation.volume | 66 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 329 | - |
dc.citation.endPage | 335 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE RISK | - |
dc.subject.keywordPlus | FISH-OIL SUPPLEMENTS | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | LONG-CHAIN | - |
dc.subject.keywordPlus | DIETARY SUPPLEMENTATION | - |
dc.subject.keywordPlus | LINOLENIC ACID | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordAuthor | fibrinogen | - |
dc.subject.keywordAuthor | marine n-3 fatty acids | - |
dc.subject.keywordAuthor | epidemiology | - |
dc.subject.keywordAuthor | Japanese | - |
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