Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans
- Authors
- Hassen, L. J.; Ueshima, H.; Curb, J. D.; Choo, J.; Lee, S.; Masaki, K.; Kadowaki, T.; Shin, C.; Evans, R. W.; Seto, T. B.; Fujiyoshi, A.; Willcox, B. J.; Sutton-Tyrrell, K.; Kadota, A.; El-Saed, A.; Miura, K.; Kuller, L. H.; Sekikawa, A.
- Issue Date
- 3월-2012
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- fibrinogen; marine n-3 fatty acids; epidemiology; Japanese
- Citation
- EUROPEAN JOURNAL OF CLINICAL NUTRITION, v.66, no.3, pp.329 - 335
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Volume
- 66
- Number
- 3
- Start Page
- 329
- End Page
- 335
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105332
- DOI
- 10.1038/ejcn.2011.155
- ISSN
- 0954-3007
- Abstract
- Background/Objectives: Numerous studies reported beneficial effects of marine n-3 fatty acids (n-3 FAs) on cardiovascular disease (CVD) and its risk factors. However, the association of marine n-3 FAs with plasma fibrinogen, a risk factor for CVD, remains uncertain. Subjects/Methods: In a population-based, cross-sectional study of 795 men aged 40-49 without CVD (262 whites in Allegheny County, Pennsylvania, USA, 302 Japanese in Kusatsu, Japan and 229 Japanese Americans in Honolulu, Hawaii, USA), we examined the association of marine n-3 FAs with plasma fibrinogen. Serum FAs were measured by capillary gas-liquid chromatography. Marine n-3 FAs were defined as the sum of docosahexaenoic, eicosapentaenoic and docosapentaenoic acids. Plasma fibrinogen was measured by an automated clot-rate assay. Multiple linear regression analyses were performed to assess the association. Results: White, Japanese and Japanese-American men had mean marine n-3 FAs levels of 3.47%, 8.78% and 4.46%, respectively. Japanese men had a significant inverse association of marine n-3 FAs with fibrinogen (standardized regression coefficient of -0.11, P=0.049), after adjusting for age, body-mass index and current smoking. The significant inverse association remained after further adjusting for diabetes, C-reactive protein, triglycerides and other variables. White or Japanese-American men did not show a significant association. Conclusions: We observed the significant inverse association of marine n-3 FAs with fibrinogen in Japanese, but not in whites or Japanese Americans. The observation suggests that marine n-3 FAs at very high levels, as seen in the Japanese, may decrease plasma fibrinogen levels. European Journal of Clinical Nutrition (2012) 66, 329-335; doi: 10.1038/ejcn.2011.155; published online 7 September 2011
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Collections - College of Nursing > Department of Nursing > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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