N-acetyl cysteine suppresses the foam cell formation that is induced by oxidized low density lipoprotein via regulation of gene expression
- Authors
- Sung, Ho Joong; Kim, Jeonghan; Kim, Yoonseo; Jang, Sung-Wuk; Ko, Jesang
- Issue Date
- 3월-2012
- Publisher
- SPRINGER
- Keywords
- Atherosclerosis; Foam cell; Reactive oxygen species; N-acetyl cysteine
- Citation
- MOLECULAR BIOLOGY REPORTS, v.39, no.3, pp.3001 - 3007
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BIOLOGY REPORTS
- Volume
- 39
- Number
- 3
- Start Page
- 3001
- End Page
- 3007
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105354
- DOI
- 10.1007/s11033-011-1062-1
- ISSN
- 0301-4851
- Abstract
- Foam cells derived from macrophages have been implicated as markers of early stage atherosclerosis development. In this study, we found that N-acetyl cysteine (NAC), a well-known inhibitor of reactive oxygen species (ROS), decreased the generation of ROS and suppressed foam cell formation in the presence of oxidized low density lipoprotein through down-regulation of cluster of differentiation 36 expression. We investigated gene expression profiles in order to determine the effects of NAC on foam cell formation using a microarray analysis. The level of apolipoprotein E, which is involved in lipid efflux, was increased and the levels of the antioxidant genes glutathione peroxidase 1 and 3 were also increased. The expression levels of the oxidative stress response and the DNA repair genes were decreased. These results were confirmed using quantitative real-time PCR. Our results indicate that oxidative stress plays an important role in foam cell formation, and that regulation of oxidation using antioxidants is a potential therapeutic method for blocking atherosclerosis development.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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