Factors Affecting the Clearance of High-risk Human Papillomavirus Infection and the Progression of Cervical Intraepithelial Neoplasia
DC Field | Value | Language |
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dc.contributor.author | Kim, J. W. | - |
dc.contributor.author | Song, S. H. | - |
dc.contributor.author | On, C. H. | - |
dc.contributor.author | Lee, J. K. | - |
dc.contributor.author | Lee, N. W. | - |
dc.contributor.author | Lee, K. W. | - |
dc.date.accessioned | 2021-09-06T08:25:15Z | - |
dc.date.available | 2021-09-06T08:25:15Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0300-0605 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105370 | - |
dc.description.abstract | OBJECTIVE: This study aimed to identify factors that predict clearance of high-risk human papillomavirus (HPV) infection and progression to cervical intraepithelial neoplasia (CIN) 2 or higher, in women with normal cervical histology or CIN 1. METHODS: A retrospective analysis was performed on 817 high-risk HPV-infected women with histologically verified CIN 1 or normal cervical histology. Patients were followed-up for a maximum of 24 months. Cervical HPV DNA tests were performed at every visit. RESULTS: At the end of follow-up, 648/817 (79.3%) patients were free from HPV infection and 66/817 patients (8.1%) progressed to CIN 2 or higher. Age, parity, cytology and viral load at diagnosis were significantly and inversely associated with HPV clearance. Cytology, viral load and presence of CIN 1 lesions were significantly associated with lesion progression. CONCLUSIONS: Cytology and high-risk HPV viral load may be useful markers for the likelihood of high-risk HPV clearance and lesion progression. Histological status, parity and marital status may also be useful factors to consider when predicting progression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | CARCINOMA IN-SITU | - |
dc.subject | NATURAL-HISTORY | - |
dc.subject | VIRAL LOAD | - |
dc.subject | NORMAL CYTOLOGY | - |
dc.subject | HPV INFECTION | - |
dc.subject | YOUNG-WOMEN | - |
dc.subject | DNA LOAD | - |
dc.subject | PERSISTENCE | - |
dc.subject | LESIONS | - |
dc.subject | POPULATION | - |
dc.title | Factors Affecting the Clearance of High-risk Human Papillomavirus Infection and the Progression of Cervical Intraepithelial Neoplasia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, J. K. | - |
dc.contributor.affiliatedAuthor | Lee, N. W. | - |
dc.identifier.doi | 10.1177/147323001204000210 | - |
dc.identifier.scopusid | 2-s2.0-84860453255 | - |
dc.identifier.wosid | 000304577100010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.40, no.2, pp.486 - 496 | - |
dc.relation.isPartOf | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | - |
dc.citation.title | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | - |
dc.citation.volume | 40 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 486 | - |
dc.citation.endPage | 496 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CARCINOMA IN-SITU | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | VIRAL LOAD | - |
dc.subject.keywordPlus | NORMAL CYTOLOGY | - |
dc.subject.keywordPlus | HPV INFECTION | - |
dc.subject.keywordPlus | YOUNG-WOMEN | - |
dc.subject.keywordPlus | DNA LOAD | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | HUMAN PAPILLOMAVIRUS | - |
dc.subject.keywordAuthor | CERVICAL INTRAEPITHELIAL NEOPLASIA | - |
dc.subject.keywordAuthor | VIRAL CLEARANCE | - |
dc.subject.keywordAuthor | PROGRESSION | - |
dc.subject.keywordAuthor | VIRAL LOAD | - |
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