Factors Affecting the Clearance of High-risk Human Papillomavirus Infection and the Progression of Cervical Intraepithelial Neoplasia
- Authors
- Kim, J. W.; Song, S. H.; On, C. H.; Lee, J. K.; Lee, N. W.; Lee, K. W.
- Issue Date
- 3월-2012
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- HUMAN PAPILLOMAVIRUS; CERVICAL INTRAEPITHELIAL NEOPLASIA; VIRAL CLEARANCE; PROGRESSION; VIRAL LOAD
- Citation
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.40, no.2, pp.486 - 496
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Volume
- 40
- Number
- 2
- Start Page
- 486
- End Page
- 496
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105370
- DOI
- 10.1177/147323001204000210
- ISSN
- 0300-0605
- Abstract
- OBJECTIVE: This study aimed to identify factors that predict clearance of high-risk human papillomavirus (HPV) infection and progression to cervical intraepithelial neoplasia (CIN) 2 or higher, in women with normal cervical histology or CIN 1. METHODS: A retrospective analysis was performed on 817 high-risk HPV-infected women with histologically verified CIN 1 or normal cervical histology. Patients were followed-up for a maximum of 24 months. Cervical HPV DNA tests were performed at every visit. RESULTS: At the end of follow-up, 648/817 (79.3%) patients were free from HPV infection and 66/817 patients (8.1%) progressed to CIN 2 or higher. Age, parity, cytology and viral load at diagnosis were significantly and inversely associated with HPV clearance. Cytology, viral load and presence of CIN 1 lesions were significantly associated with lesion progression. CONCLUSIONS: Cytology and high-risk HPV viral load may be useful markers for the likelihood of high-risk HPV clearance and lesion progression. Histological status, parity and marital status may also be useful factors to consider when predicting progression.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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