Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Protective effect of triphala on radiation induced acute intestinal mucosal damage in Sprague Dawley rats

Full metadata record
DC Field Value Language
dc.contributor.authorYoon, Won Sup-
dc.contributor.authorKim, Chul Yong-
dc.contributor.authorYang, Dae Sik-
dc.contributor.authorPark, Young Je-
dc.contributor.authorPark, Won-
dc.contributor.authorAhn, Yong Chan-
dc.contributor.authorKim, Seok-Hyung-
dc.contributor.authorKwon, Ghee Young-
dc.date.accessioned2021-09-06T08:35:21Z-
dc.date.available2021-09-06T08:35:21Z-
dc.date.issued2012-03-
dc.identifier.issn0019-5189-
dc.identifier.issn0975-1009-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/105430-
dc.description.abstractAim of the study was to determine protective effect of triphala on radiation-induced rectal mucosal damage. Male Sprague Dawley rats (30) were divided into 5 groups. Rats in group A were sham irradiated and rats in group B underwent only irradiation. Rats in group C were administered triphala 1 g/kg/day orally for 5 consecutive days before irradiation. Rats in group D and E were administered triphala 1 and 1.5 g/kg/day orally for 10 consecutive days, respectively. Rectal mucosal damage was induced by a single fraction of 12.5Gy gamma irradiation (Ir-192) on 5th day. All the rats were autopsied on 11th day and histological changes in surface epithelium, glands, and lamina propria were assessed. Proctitis showed significant improvement in surface epithelium (P<0.024), glands (P<0.000) and lamina propria (P<0.002) in group E compared to group B. Rats in group E showed significantly less change in glands (P<0.000) compared to rats in group D, All histological variables (surface epithelium, P<0.001; glands, P<0.000; lamina propria, P<0.003) compared to rats in group C. In a Tukey-b test, group E had a significantly recovered grade for glands (P<0.000) compared to groups B, C and D. Results of the present study showed that high-dose triphala improved radiation-induced damage of glands.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherNATL INST SCIENCE COMMUNICATION-NISCAIR-
dc.titleProtective effect of triphala on radiation induced acute intestinal mucosal damage in Sprague Dawley rats-
dc.typeArticle-
dc.publisher.location인도-
dc.identifier.scopusid2-s2.0-84863368605-
dc.identifier.wosid000301313300003-
dc.identifier.bibliographicCitationINDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, v.50, no.3, pp 195 - 200-
dc.citation.titleINDIAN JOURNAL OF EXPERIMENTAL BIOLOGY-
dc.citation.volume50-
dc.citation.number3-
dc.citation.startPage195-
dc.citation.endPage200-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaLife Sciences & Biomedicine - Other Topics-
dc.relation.journalWebOfScienceCategoryBiology-
dc.subject.keywordPlusEPIDERMAL-GROWTH-FACTOR-
dc.subject.keywordPlusPROSTATE-CANCER-
dc.subject.keywordPlusDOUBLE-BLIND-
dc.subject.keywordPlusCONFORMAL RADIOTHERAPY-
dc.subject.keywordPlusPELVIC RADIOTHERAPY-
dc.subject.keywordPlusDOSE-RESPONSE-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusPROCTITIS-
dc.subject.keywordPlusTRIAL-
dc.subject.keywordPlusMICE-
dc.subject.keywordAuthorEpithelium-
dc.subject.keywordAuthorGlands-
dc.subject.keywordAuthorLamina propria-
dc.subject.keywordAuthorProctitis-
dc.subject.keywordAuthorRadiation protection-
dc.subject.keywordAuthorTriphala-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Chul Yong photo

Kim, Chul Yong
College of Medicine (Department of Medical Science)
Read more

Altmetrics

Total Views & Downloads

BROWSE