Protective effect of triphala on radiation induced acute intestinal mucosal damage in Sprague Dawley rats
- Authors
- Yoon, Won Sup; Kim, Chul Yong; Yang, Dae Sik; Park, Young Je; Park, Won; Ahn, Yong Chan; Kim, Seok-Hyung; Kwon, Ghee Young
- Issue Date
- 3월-2012
- Publisher
- NATL INST SCIENCE COMMUNICATION-NISCAIR
- Keywords
- Epithelium; Glands; Lamina propria; Proctitis; Radiation protection; Triphala
- Citation
- INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, v.50, no.3, pp.195 - 200
- Indexed
- SCIE
SCOPUS
- Journal Title
- INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
- Volume
- 50
- Number
- 3
- Start Page
- 195
- End Page
- 200
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105430
- ISSN
- 0019-5189
- Abstract
- Aim of the study was to determine protective effect of triphala on radiation-induced rectal mucosal damage. Male Sprague Dawley rats (30) were divided into 5 groups. Rats in group A were sham irradiated and rats in group B underwent only irradiation. Rats in group C were administered triphala 1 g/kg/day orally for 5 consecutive days before irradiation. Rats in group D and E were administered triphala 1 and 1.5 g/kg/day orally for 10 consecutive days, respectively. Rectal mucosal damage was induced by a single fraction of 12.5Gy gamma irradiation (Ir-192) on 5th day. All the rats were autopsied on 11th day and histological changes in surface epithelium, glands, and lamina propria were assessed. Proctitis showed significant improvement in surface epithelium (P<0.024), glands (P<0.000) and lamina propria (P<0.002) in group E compared to group B. Rats in group E showed significantly less change in glands (P<0.000) compared to rats in group D, All histological variables (surface epithelium, P<0.001; glands, P<0.000; lamina propria, P<0.003) compared to rats in group C. In a Tukey-b test, group E had a significantly recovered grade for glands (P<0.000) compared to groups B, C and D. Results of the present study showed that high-dose triphala improved radiation-induced damage of glands.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.