Overlap of dyspepsia and gastroesophageal reflux in the general population: one disease or distinct entities?
- Authors
- Choung, R. S.; Locke, G. R., III; Schleck, C. D.; Zinsmeister, A. R.; Talley, N. J.
- Issue Date
- 3월-2012
- Publisher
- WILEY
- Keywords
- dyspepsia; gastroesophageal reflux; population-based study
- Citation
- NEUROGASTROENTEROLOGY AND MOTILITY, v.24, no.3, pp.229 - E106
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROGASTROENTEROLOGY AND MOTILITY
- Volume
- 24
- Number
- 3
- Start Page
- 229
- End Page
- E106
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105435
- DOI
- 10.1111/j.1365-2982.2011.01845.x
- ISSN
- 1350-1925
- Abstract
- Background The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap. Methods In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/ or acid regurgitation. Key Results Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia- GER overlap vs GER alone or dyspepsia alone [OR = 1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia- GER overlap vs. GER alone or dyspepsia alone [OR = 1.4 (1.1, 1.7), OR = 1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia- GER overlap vs dyspepsia alone [OR = 2.4 (1.5, 3.8)]. Conclusions & Inferences Dyspepsia- GER overlap is common in the population and is greater than expected by chance.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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