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Human lactoferrin suppresses TNF-alpha-induced intercellular adhesion molecule-1 expression via competition with NF-kappa B in endothelial cells

Authors
Kim, Chan WooLee, Tae HoonPark, Keun HyungChoi, Sang-YunKim, Jiyoung
Issue Date
3-Feb-2012
Publisher
ELSEVIER SCIENCE BV
Keywords
Lactoferrin; Inflammation; Intercellular adhesion molecule-1 (ICAM-1); NF-kappa B; Endothelial cell
Citation
FEBS LETTERS, v.586, no.3, pp.229 - 234
Indexed
SCIE
SCOPUS
Journal Title
FEBS LETTERS
Volume
586
Number
3
Start Page
229
End Page
234
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/105477
DOI
10.1016/j.febslet.2011.12.011
ISSN
0014-5793
Abstract
Lactoferrin (Lf) is known to have anti-inflammatory activity, but the mechanisms of action by Lf remain to be elucidated. Here, we demonstrated that TNF-alpha-induced expression of intercellular adhesion molecule-1 (ICAM-1) was down-regulated by Lf in a DNA-binding dependent manner at transcriptional level in endothelial cells. Our results showed that Lf bound to a DNA region in the ICAM-1 promoter in vitro as well as in chromatin context. Lf inhibited binding of NF-kappa B to a proximal NF-kappa B site in ICAM-1 promoter. This type of repression represents an additional mechanism for the action of Lf in regulation of gene expression. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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