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Recent advances in idiopathic pulmonary fibrosis

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dc.contributor.authorPark, S.-
dc.contributor.authorLee, E.J.-
dc.date.accessioned2021-09-06T09:42:41Z-
dc.date.available2021-09-06T09:42:41Z-
dc.date.created2021-06-17-
dc.date.issued2013-
dc.identifier.issn1738-3536-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/105872-
dc.description.abstractThe concept on idiopathic pulmonary fibrosis (IPF) pathogenesis has progressed from chronic inflammation to aberrant wounding healing and even more to the current paradigms of a multifactorial and heterogeneous disease process. Despite the growth of clinical trials for IPF, most of the results, including N-acetylcysteine combination, warfarin, and bosentan, were disappointing. On the other hand, there have been a number of important developments; the foremost is the licensing of pirfenidone in Europe and Asia. In this article, we briefly review the recent knowledge of pathogenesis of IPF. We also summarize the recent clinical trials regarding the management of IPF. Copyright©2013. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.subjectacetylcysteine-
dc.subjectazathioprine-
dc.subjectbosentan-
dc.subjectgelatinase A-
dc.subjectgelatinase B-
dc.subjectinterstitial collagenase-
dc.subjectlosartan-
dc.subjectmatrilysin-
dc.subjectneutrophil collagenase-
dc.subjectnintedanib-
dc.subjectpirfenidone-
dc.subjectplacebo-
dc.subjectprednisone-
dc.subjectthalidomide-
dc.subjectwarfarin-
dc.subjectaging-
dc.subjectairway remodeling-
dc.subjectaminotransferase blood level-
dc.subjectangiogenesis-
dc.subjectcell differentiation-
dc.subjectcoughing-
dc.subjectdrug efficacy-
dc.subjectdrug withdrawal-
dc.subjectexploratory research-
dc.subjectfibrosing alveolitis-
dc.subjectforced vital capacity-
dc.subjectgastrointestinal symptom-
dc.subjectgenotype environment interaction-
dc.subjecthuman-
dc.subjectlung alveolus cell type 1-
dc.subjectlung alveolus epithelium-
dc.subjectlung injury-
dc.subjectmesothelium cell-
dc.subjectmonotherapy-
dc.subjectmyofibroblast-
dc.subjectpericyte-
dc.subjectphase 3 clinical trial (topic)-
dc.subjectpilot study-
dc.subjectrandomized controlled trial (topic)-
dc.subjectreview-
dc.subjectside effect-
dc.subjecttreatment withdrawal-
dc.titleRecent advances in idiopathic pulmonary fibrosis-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, E.J.-
dc.identifier.doi10.4046/trd.2013.74.1.1-
dc.identifier.scopusid2-s2.0-84874475811-
dc.identifier.bibliographicCitationTuberculosis and Respiratory Diseases, v.74, no.1, pp.1 - 6-
dc.relation.isPartOfTuberculosis and Respiratory Diseases-
dc.citation.titleTuberculosis and Respiratory Diseases-
dc.citation.volume74-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage6-
dc.type.rimsART-
dc.type.docTypeReview-
dc.identifier.kciidART001741048-
dc.description.journalClass1-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.subject.keywordPlusacetylcysteine-
dc.subject.keywordPlusazathioprine-
dc.subject.keywordPlusbosentan-
dc.subject.keywordPlusgelatinase A-
dc.subject.keywordPlusgelatinase B-
dc.subject.keywordPlusinterstitial collagenase-
dc.subject.keywordPluslosartan-
dc.subject.keywordPlusmatrilysin-
dc.subject.keywordPlusneutrophil collagenase-
dc.subject.keywordPlusnintedanib-
dc.subject.keywordPluspirfenidone-
dc.subject.keywordPlusplacebo-
dc.subject.keywordPlusprednisone-
dc.subject.keywordPlusthalidomide-
dc.subject.keywordPluswarfarin-
dc.subject.keywordPlusaging-
dc.subject.keywordPlusairway remodeling-
dc.subject.keywordPlusaminotransferase blood level-
dc.subject.keywordPlusangiogenesis-
dc.subject.keywordPluscell differentiation-
dc.subject.keywordPluscoughing-
dc.subject.keywordPlusdrug efficacy-
dc.subject.keywordPlusdrug withdrawal-
dc.subject.keywordPlusexploratory research-
dc.subject.keywordPlusfibrosing alveolitis-
dc.subject.keywordPlusforced vital capacity-
dc.subject.keywordPlusgastrointestinal symptom-
dc.subject.keywordPlusgenotype environment interaction-
dc.subject.keywordPlushuman-
dc.subject.keywordPluslung alveolus cell type 1-
dc.subject.keywordPluslung alveolus epithelium-
dc.subject.keywordPluslung injury-
dc.subject.keywordPlusmesothelium cell-
dc.subject.keywordPlusmonotherapy-
dc.subject.keywordPlusmyofibroblast-
dc.subject.keywordPluspericyte-
dc.subject.keywordPlusphase 3 clinical trial (topic)-
dc.subject.keywordPluspilot study-
dc.subject.keywordPlusrandomized controlled trial (topic)-
dc.subject.keywordPlusreview-
dc.subject.keywordPlusside effect-
dc.subject.keywordPlustreatment withdrawal-
dc.subject.keywordAuthorClinical trial-
dc.subject.keywordAuthorEtiology-
dc.subject.keywordAuthorIdiopathic pulmonary fibrosis-
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