Effects of 17β-estradiol and estrogen receptor antagonists on the proliferation of gastric cancer cell lines
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, M.-J. | - |
dc.contributor.author | Cho, S.-I. | - |
dc.contributor.author | Lee, K.-O. | - |
dc.contributor.author | Han, H.-J. | - |
dc.contributor.author | Song, T.-J. | - |
dc.contributor.author | Park, S.-H. | - |
dc.date.accessioned | 2021-09-06T09:58:33Z | - |
dc.date.available | 2021-09-06T09:58:33Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2093-582X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105970 | - |
dc.description.abstract | Purpose: The aims of this study were as follow: 1) to describe the expression status of estrogen receptor-α and-β mRNAs in five gastric carcinoma cell lines; 2) to evaluate in vitro the effects of 17β-estradiol and estrogen receptor antagonists on the proliferation of the cell lines. Materials and Methods: Detection of estrogen receptor-α and estrogen receptor-β mRNA in five human gastric cancer cell lines (AGS, KATO III, MKN28, MKN45 and MKN74) was made by the reverse transcription-polymerase chain reaction system. To evaluate the effect of 17β-estradiol and estrogen receptor antagonists on the proliferation of gastric cancer cell line, the cell lines which expressed both estrogen receptors were chosen and treated with 17β-estradiol and estrogen receptor antagonists (methyl-piperidino-pyrazole and pyrazolo [1,5-a] pyrimidine). Cell proliferation was assessed with the methylthiazol tetrazolium test. Results: Estrogen receptor-α and estrogen receptor-β mRNAs were expressed in three (KATO III, MKN28 and MKN45) and all of the five gastric cancer cell lines, respectively. At higher concentrations, 17β-estradiol inhibited cell growth of MKN28, MKN45 and KATO III cell lines. Neither estrogen receptor-α nor estrogen receptor-β antagonist blocked the anti-proliferative effect of 17β-estradiol. Conclusions: Our results indicate that estrogen receptor-β mRNAs are preferentially expressed in gastric cancers and also imply that hormone therapy rather than estrogen receptor blockers may be a useful strategy for the treatment of estrogen receptor-β positive gastric cancer. Its therapeutic significance in gastric cancer are, however, limited until more evidence of the roles of estrogen receptors in the gastric cancer are accumulated. © 2013 by The Korean Gastric Cancer Association. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | estradiol | - |
dc.subject | estrogen receptor alpha | - |
dc.subject | estrogen receptor beta | - |
dc.subject | methyl piperidino pyrazole | - |
dc.subject | pyrazolo [1, 5 a] pyrimidine derivative | - |
dc.subject | selective estrogen receptor modulator | - |
dc.subject | unclassified drug | - |
dc.subject | article | - |
dc.subject | cancer cell culture | - |
dc.subject | cancer inhibition | - |
dc.subject | cell proliferation | - |
dc.subject | cell viability | - |
dc.subject | controlled study | - |
dc.subject | human | - |
dc.subject | human cell | - |
dc.subject | protein expression | - |
dc.subject | reverse transcription polymerase chain reaction | - |
dc.subject | stomach cancer | - |
dc.title | Effects of 17β-estradiol and estrogen receptor antagonists on the proliferation of gastric cancer cell lines | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, H.-J. | - |
dc.contributor.affiliatedAuthor | Song, T.-J. | - |
dc.contributor.affiliatedAuthor | Park, S.-H. | - |
dc.identifier.doi | 10.5230/jgc.2013.13.3.172 | - |
dc.identifier.scopusid | 2-s2.0-84885051124 | - |
dc.identifier.bibliographicCitation | Journal of Gastric Cancer, v.13, no.3, pp.172 - 178 | - |
dc.relation.isPartOf | Journal of Gastric Cancer | - |
dc.citation.title | Journal of Gastric Cancer | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | 178 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001806287 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordPlus | estradiol | - |
dc.subject.keywordPlus | estrogen receptor alpha | - |
dc.subject.keywordPlus | estrogen receptor beta | - |
dc.subject.keywordPlus | methyl piperidino pyrazole | - |
dc.subject.keywordPlus | pyrazolo [1, 5 a] pyrimidine derivative | - |
dc.subject.keywordPlus | selective estrogen receptor modulator | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cancer cell culture | - |
dc.subject.keywordPlus | cancer inhibition | - |
dc.subject.keywordPlus | cell proliferation | - |
dc.subject.keywordPlus | cell viability | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | reverse transcription polymerase chain reaction | - |
dc.subject.keywordPlus | stomach cancer | - |
dc.subject.keywordAuthor | Cell line | - |
dc.subject.keywordAuthor | Estrogen | - |
dc.subject.keywordAuthor | Estrogens | - |
dc.subject.keywordAuthor | Receptors | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
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