Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson's Disease
DC Field | Value | Language |
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dc.contributor.author | Jeong, E. | - |
dc.contributor.author | Oh, S.Y. | - |
dc.contributor.author | Pahk, K. | - |
dc.contributor.author | Lee, C.-N. | - |
dc.contributor.author | Park, K.-W. | - |
dc.contributor.author | Lee, J.S. | - |
dc.contributor.author | Cheon, G.J. | - |
dc.contributor.author | Choe, J.G. | - |
dc.date.accessioned | 2021-09-06T10:06:18Z | - |
dc.date.available | 2021-09-06T10:06:18Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106018 | - |
dc.description.abstract | Purpose: The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease. Methods: Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic Anatomical Map (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method. Results: All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manual methods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region. Conclusions: Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method. © 2013 Korean Society of Nuclear Medicine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | n 3 fluoropropyl 2beta carboxymethoxy 3beta (4 iodophenyl)nortropane f 18 | - |
dc.subject | radiopharmaceutical agent | - |
dc.subject | unclassified drug | - |
dc.subject | adult | - |
dc.subject | aged | - |
dc.subject | analytic method | - |
dc.subject | article | - |
dc.subject | asymmetry index | - |
dc.subject | brain mapping | - |
dc.subject | cerebellum | - |
dc.subject | clinical article | - |
dc.subject | computed tomography scanner | - |
dc.subject | controlled study | - |
dc.subject | de novo Parkinson disease | - |
dc.subject | diagnostic accuracy | - |
dc.subject | diagnostic test accuracy study | - |
dc.subject | disease severity | - |
dc.subject | feasibility study | - |
dc.subject | female | - |
dc.subject | high performance liquid chromatography | - |
dc.subject | Hoehn and Yahr scale | - |
dc.subject | human | - |
dc.subject | intermethod comparison | - |
dc.subject | Korean Statistical Probabilistic Anatomical Map | - |
dc.subject | male | - |
dc.subject | occipital cortex | - |
dc.subject | Parkinson disease | - |
dc.subject | positron emission tomography | - |
dc.subject | priority journal | - |
dc.subject | Putamen to caudate ratio | - |
dc.subject | quantitative analysis | - |
dc.subject | sensitivity and specificity | - |
dc.subject | Unified Parkinson Disease Rating Scale | - |
dc.title | Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson's Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, K.-W. | - |
dc.contributor.affiliatedAuthor | Choe, J.G. | - |
dc.identifier.doi | 10.1007/s13139-013-0196-6 | - |
dc.identifier.scopusid | 2-s2.0-84877808086 | - |
dc.identifier.bibliographicCitation | Nuclear Medicine and Molecular Imaging, v.47, no.2, pp.73 - 80 | - |
dc.relation.isPartOf | Nuclear Medicine and Molecular Imaging | - |
dc.citation.title | Nuclear Medicine and Molecular Imaging | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001775632 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | radiopharmaceutical agent | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | analytic method | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | asymmetry index | - |
dc.subject.keywordPlus | brain mapping | - |
dc.subject.keywordPlus | cerebellum | - |
dc.subject.keywordPlus | clinical article | - |
dc.subject.keywordPlus | computed tomography scanner | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | de novo Parkinson disease | - |
dc.subject.keywordPlus | diagnostic accuracy | - |
dc.subject.keywordPlus | diagnostic test accuracy study | - |
dc.subject.keywordPlus | disease severity | - |
dc.subject.keywordPlus | feasibility study | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | high performance liquid chromatography | - |
dc.subject.keywordPlus | Hoehn and Yahr scale | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | intermethod comparison | - |
dc.subject.keywordPlus | Korean Statistical Probabilistic Anatomical Map | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | occipital cortex | - |
dc.subject.keywordPlus | Parkinson disease | - |
dc.subject.keywordPlus | positron emission tomography | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | Putamen to caudate ratio | - |
dc.subject.keywordPlus | quantitative analysis | - |
dc.subject.keywordPlus | sensitivity and specificity | - |
dc.subject.keywordPlus | Unified Parkinson Disease Rating Scale | - |
dc.subject.keywordPlus | n 3 fluoropropyl 2beta carboxymethoxy 3beta (4 iodophenyl)nortropane f 18 | - |
dc.subject.keywordAuthor | Dopamine transporter (DAT) | - |
dc.subject.keywordAuthor | F-18 FP-CIT PET | - |
dc.subject.keywordAuthor | Korean statistical probabilistic anatomical map (KSPAM) | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Template-based quantitative analysis | - |
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