Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson's Disease
- Authors
- Jeong, E.; Oh, S.Y.; Pahk, K.; Lee, C.-N.; Park, K.-W.; Lee, J.S.; Cheon, G.J.; Choe, J.G.
- Issue Date
- 2013
- Keywords
- Dopamine transporter (DAT); F-18 FP-CIT PET; Korean statistical probabilistic anatomical map (KSPAM); Parkinson' s disease; Template-based quantitative analysis
- Citation
- Nuclear Medicine and Molecular Imaging, v.47, no.2, pp.73 - 80
- Indexed
- SCOPUS
KCI
- Journal Title
- Nuclear Medicine and Molecular Imaging
- Volume
- 47
- Number
- 2
- Start Page
- 73
- End Page
- 80
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106018
- DOI
- 10.1007/s13139-013-0196-6
- ISSN
- 1869-3474
- Abstract
- Purpose: The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease. Methods: Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic Anatomical Map (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method. Results: All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manual methods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region. Conclusions: Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method. © 2013 Korean Society of Nuclear Medicine.
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