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Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome.

Authors
Kim, H.R.Lee, Y.S.Yim, H.J.Lee, H.J.Ryu, J.Y.Lee, H.J.Yoon, E.L.Lee, S.J.Hyun, J.J.Jung, S.W.Koo, J.S.Choung, R.S.Lee, S.W.Choi, J.H.
Issue Date
2013
Keywords
Terlipressin; Necrosis; Hepatorenal syndrome
Citation
Clinical and molecular hepatology, v.19, no.4, pp.417 - 420
Indexed
SCOPUS
KCI
Journal Title
Clinical and molecular hepatology
Volume
19
Number
4
Start Page
417
End Page
420
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106025
DOI
10.3350/cmh.2013.19.4.417
ISSN
2287-2728
Abstract
Terlipressin is a vasopressin analogue that is widely used in the treatment of hepatorenal syndrome or variceal bleeding. Because it acts mainly on splanchnic vessels, terlipressin has a lower incidence of severe ischemic complications than does vasopressin. However, it can still lead to serious complications such as myocardial infarction, skin necrosis, or bowel ischemia. Herein we report a case of severe ischemic bowel necrosis in a 46-year-old cirrhotic patient treated with terlipressin. Although the patient received bowel resection, death occurred due to ongoing hypotension and metabolic acidosis. Attention should be paid to patients complaining of abdominal pain during treatment with terlipressin.
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