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Cd2+ binds to Atx1 and affects the physical interaction between Atx1 and Ccc2 in Saccharomyces cerevisiae
- Authors
- Heo, Dong-Hyuk; Baek, In-Joon; Kang, Hyun-Jun; Kim, Ji-Hyun; Chang, Miwha; Kang, Chang-Min; Yun, Cheol-Won
- Issue Date
- 2월-2012
- Publisher
- SPRINGER
- Keywords
- Atx1; Cadmium; Ccc2; Copper; Saccharomyces cerevisiae
- Citation
- BIOTECHNOLOGY LETTERS, v.34, no.2, pp.303 - 307
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 34
- Number
- 2
- Start Page
- 303
- End Page
- 307
- ISSN
- 0141-5492
- Abstract
- The ATX1 deletion strain of Saccharomyces cerevisiae is more resistant to Cd2+ than the wild-type. To investigate the function of Atx1 in Cd2+ toxicity, we used a metal-binding assay to study the interaction between Atx1 and Cd2+ in vitro. Using circular dichroism and two-hybrid analyses, we found that Atx1 can bind Cd2+ specifically and that Cd2+ binding to Atx1 affects the physical interaction between Atx1 and Ccc2. These results imply that Atx1 delivers Cd2+ to Ccc2 and that this delivery is, at least in part, responsible for Cd2+ toxicity in S. cerevisiae.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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