Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1
DC Field | Value | Language |
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dc.contributor.author | Lee, Sunghee | - |
dc.contributor.author | Curb, J. David | - |
dc.contributor.author | Kadowaki, Takashi | - |
dc.contributor.author | Evans, Rhobert W. | - |
dc.contributor.author | Miura, Katsuyuki | - |
dc.contributor.author | Takamiya, Tomoko | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | El-Saed, Aiman | - |
dc.contributor.author | Choo, Jina | - |
dc.contributor.author | Fujiyoshi, Akira | - |
dc.contributor.author | Otake, Teruo | - |
dc.contributor.author | Kadowaki, Sayaka | - |
dc.contributor.author | Seto, Todd | - |
dc.contributor.author | Masaki, Kamal | - |
dc.contributor.author | Edmundowicz, Daniel | - |
dc.contributor.author | Ueshima, Hirotsugu | - |
dc.contributor.author | Kuller, Lewis H. | - |
dc.contributor.author | Sekikawa, Akira | - |
dc.date.accessioned | 2021-09-06T10:34:40Z | - |
dc.date.available | 2021-09-06T10:34:40Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106167 | - |
dc.description.abstract | Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.subject | LINOLEIC-ACID | - |
dc.subject | PLATELET-FUNCTION | - |
dc.subject | JAPANESE MEN | - |
dc.subject | WHITE MEN | - |
dc.subject | DIETARY | - |
dc.subject | RISK | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | DISEASE | - |
dc.subject | SUPPLEMENTATION | - |
dc.subject | EXPRESSION | - |
dc.title | Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.contributor.affiliatedAuthor | Choo, Jina | - |
dc.identifier.doi | 10.1017/S0007114511003199 | - |
dc.identifier.scopusid | 2-s2.0-84856748913 | - |
dc.identifier.wosid | 000299936700013 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF NUTRITION, v.107, no.4, pp.567 - 572 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.title | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.volume | 107 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 567 | - |
dc.citation.endPage | 572 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | LINOLEIC-ACID | - |
dc.subject.keywordPlus | PLATELET-FUNCTION | - |
dc.subject.keywordPlus | JAPANESE MEN | - |
dc.subject.keywordPlus | WHITE MEN | - |
dc.subject.keywordPlus | DIETARY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | SUPPLEMENTATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Plasminogen activator inhibitor-1 | - |
dc.subject.keywordAuthor | Linoleic acid | - |
dc.subject.keywordAuthor | Fatty acids | - |
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