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Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1

Authors
Lee, SungheeCurb, J. DavidKadowaki, TakashiEvans, Rhobert W.Miura, KatsuyukiTakamiya, TomokoShin, CholEl-Saed, AimanChoo, JinaFujiyoshi, AkiraOtake, TeruoKadowaki, SayakaSeto, ToddMasaki, KamalEdmundowicz, DanielUeshima, HirotsuguKuller, Lewis H.Sekikawa, Akira
Issue Date
2월-2012
Publisher
CAMBRIDGE UNIV PRESS
Keywords
Plasminogen activator inhibitor-1; Linoleic acid; Fatty acids
Citation
BRITISH JOURNAL OF NUTRITION, v.107, no.4, pp.567 - 572
Indexed
SCIE
SCOPUS
Journal Title
BRITISH JOURNAL OF NUTRITION
Volume
107
Number
4
Start Page
567
End Page
572
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106167
DOI
10.1017/S0007114511003199
ISSN
0007-1145
Abstract
Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.
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