Severe Osteomyelitis as a Complication of Tokyo-172 BCG Vaccination
- Authors
- Kwon, Hyo Jin; Chung, Bo Hyun; Choi, Byung Min; Park, Kyung Un; Kim, Yun Kyung
- Issue Date
- 2월-2012
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Osteomyelitis; Complication; Bacilli Calmette-Guerin Vaccination
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.27, no.2, pp.221 - 224
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 27
- Number
- 2
- Start Page
- 221
- End Page
- 224
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106169
- DOI
- 10.3346/jkms.2012.27.2.221
- ISSN
- 1011-8934
- Abstract
- The bacilli Calmette-Guerin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic, evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive far BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.
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