Increased Carotid Intima-Media Thickness and Plasma Homocysteine Levels Predict Cardiovascular and All-Cause Death: A Population-Based Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Jung, Jin-Man | - |
dc.contributor.author | Kwon, Do Young | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Jo, Inho | - |
dc.contributor.author | Jo, Sangmee Ahn | - |
dc.contributor.author | Park, Moon Ho | - |
dc.date.accessioned | 2021-09-06T11:12:25Z | - |
dc.date.available | 2021-09-06T11:12:25Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0014-3022 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106413 | - |
dc.description.abstract | Background: There is still debate over the utility of carotid intima-media thickness (C-IMT) or carotid plaque in predicting future cardiovascular events and death. Additionally, the importance of plasma homocysteine levels was raised as a predictor of cardiovascular events and death. Methods: 1,391 subjects were recruited from the Ansan Geriatric cohort. We used B-mode carotid ultrasonography to assess C-IMT and plaque, measuring average maximal IMT and average mean IMT through 6-8 measurements of far-wall IMT in both common carotid arteries. We evaluated the presence of plaque in carotid segments. Multivariable Cox regression analysis was used to predict both cardiovascular and all-cause mortality. Results: During a mean follow-up of 62.4 +/- 12.4 months, 71 subjects (5.12%) died and 23(1.66%) died of cardiovascular causes. Multivariable Cox regression analysis found the predictors of cardiovascular mortality to be average maximal IMT (HR = 3.709; 95% CI: 1.202-11.446) and plasma homocysteine (HR = 1.057; 95% CI: 1.012-1.103). All-cause mortality was independently associated with C-IMT (average maximal and average mean IMT) and plasma homocysteine. Conclusions: C-IMT and plasma homocysteine levels were found to predict cardiovascular and all-cause mortality independently of the presence of carotid plaque and other cardiovascular risk factors. Copyright (C) 2013 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | CORONARY-HEART-DISEASE | - |
dc.subject | B-MODE ULTRASOUND | - |
dc.subject | ATHEROSCLEROSIS RISK | - |
dc.subject | SERUM HOMOCYSTEINE | - |
dc.subject | OLDER-ADULTS | - |
dc.subject | MORTALITY | - |
dc.subject | PLAQUE | - |
dc.subject | EVENTS | - |
dc.subject | STROKE | - |
dc.subject | PEOPLE | - |
dc.title | Increased Carotid Intima-Media Thickness and Plasma Homocysteine Levels Predict Cardiovascular and All-Cause Death: A Population-Based Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Jin-Man | - |
dc.contributor.affiliatedAuthor | Kwon, Do Young | - |
dc.contributor.affiliatedAuthor | Han, Changsu | - |
dc.contributor.affiliatedAuthor | Park, Moon Ho | - |
dc.identifier.doi | 10.1159/000343807 | - |
dc.identifier.scopusid | 2-s2.0-84883144057 | - |
dc.identifier.wosid | 000323794600001 | - |
dc.identifier.bibliographicCitation | EUROPEAN NEUROLOGY, v.70, no.1-2, pp.1 - 5 | - |
dc.relation.isPartOf | EUROPEAN NEUROLOGY | - |
dc.citation.title | EUROPEAN NEUROLOGY | - |
dc.citation.volume | 70 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | B-MODE ULTRASOUND | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS RISK | - |
dc.subject.keywordPlus | SERUM HOMOCYSTEINE | - |
dc.subject.keywordPlus | OLDER-ADULTS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | PLAQUE | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | PEOPLE | - |
dc.subject.keywordAuthor | Intima-media thickness | - |
dc.subject.keywordAuthor | Carotid plaque | - |
dc.subject.keywordAuthor | Homocysteine | - |
dc.subject.keywordAuthor | Mortality | - |
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