Increased Carotid Intima-Media Thickness and Plasma Homocysteine Levels Predict Cardiovascular and All-Cause Death: A Population-Based Cohort Study
- Authors
- Jung, Jin-Man; Kwon, Do Young; Han, Changsu; Jo, Inho; Jo, Sangmee Ahn; Park, Moon Ho
- Issue Date
- 2013
- Publisher
- KARGER
- Keywords
- Intima-media thickness; Carotid plaque; Homocysteine; Mortality
- Citation
- EUROPEAN NEUROLOGY, v.70, no.1-2, pp.1 - 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN NEUROLOGY
- Volume
- 70
- Number
- 1-2
- Start Page
- 1
- End Page
- 5
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106413
- DOI
- 10.1159/000343807
- ISSN
- 0014-3022
- Abstract
- Background: There is still debate over the utility of carotid intima-media thickness (C-IMT) or carotid plaque in predicting future cardiovascular events and death. Additionally, the importance of plasma homocysteine levels was raised as a predictor of cardiovascular events and death. Methods: 1,391 subjects were recruited from the Ansan Geriatric cohort. We used B-mode carotid ultrasonography to assess C-IMT and plaque, measuring average maximal IMT and average mean IMT through 6-8 measurements of far-wall IMT in both common carotid arteries. We evaluated the presence of plaque in carotid segments. Multivariable Cox regression analysis was used to predict both cardiovascular and all-cause mortality. Results: During a mean follow-up of 62.4 +/- 12.4 months, 71 subjects (5.12%) died and 23(1.66%) died of cardiovascular causes. Multivariable Cox regression analysis found the predictors of cardiovascular mortality to be average maximal IMT (HR = 3.709; 95% CI: 1.202-11.446) and plasma homocysteine (HR = 1.057; 95% CI: 1.012-1.103). All-cause mortality was independently associated with C-IMT (average maximal and average mean IMT) and plasma homocysteine. Conclusions: C-IMT and plasma homocysteine levels were found to predict cardiovascular and all-cause mortality independently of the presence of carotid plaque and other cardiovascular risk factors. Copyright (C) 2013 S. Karger AG, Basel
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