Interleukin-4, interleukin-4 receptor, and interleukin-18 polymorphisms and rheumatoid arthritis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-06T11:13:44Z | - |
dc.date.available | 2021-09-06T11:13:44Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0882-0139 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106421 | - |
dc.description.abstract | Objective: The aim of this study was to determine whether the functional interleukin-4 (IL-4) -590 C/T, IL-4 receptor (IL-4R) 1902 G/A, IL-18 -607 C/A, and -137 G/C polymorphisms polymorphisms confer susceptibility to rheumatoid arthritis (RA). Methods: Meta-analysis was conducted on the associations between these IL-4, IL-4R, and IL-18 polymorphisms and RA. Results: A total of 12 comparative studies were included in this meta-analysis. Meta-analysis of the IL-4 -590 C/T polymorphism showed an association in all study subjects and Europeans (OR for the TT genotype = 2.280, 95% CI = 1.315-3.952, p = 0.003; OR = 2.139, 95% CI = 1.089-4.199, p = 0.027). However, meta-analysis showed no association between RA and the IL-4R 1902 G allele in all study subjects and Europeans. Meta-analysis showed no association between RA and the IL-18 -607 C allele (OR = 1.159, 95% CI = 0.967-1.387, p = 0.110). Meta-analysis of the IL-18 -137 G/C polymorphism revealed no association between RA and the IL-18 -137 G/C polymorphism. Conclusions: This meta-analysis demonstrates that the IL-4 -590 T/C polymorphism is associated with susceptibility to RA in Europeans, but the IL-4R+1902 G/A, IL-18 -607 C/A and -137 G/C polymorphisms are not associated with RA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject | PROMOTER POLYMORPHISM | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | IL-6 GENE | - |
dc.subject | ASSOCIATION | - |
dc.subject | DISEASE | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | MECHANISMS | - |
dc.subject | EXPRESSION | - |
dc.title | Interleukin-4, interleukin-4 receptor, and interleukin-18 polymorphisms and rheumatoid arthritis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.3109/08820139.2013.804084 | - |
dc.identifier.scopusid | 2-s2.0-84880895470 | - |
dc.identifier.wosid | 000322178000001 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGICAL INVESTIGATIONS, v.42, no.6, pp.455 - 469 | - |
dc.relation.isPartOf | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.citation.title | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.citation.volume | 42 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 455 | - |
dc.citation.endPage | 469 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | IL-6 GENE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | interleukin-4 | - |
dc.subject.keywordAuthor | IL-18 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | meta-analysis | - |
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