Interleukin-4, interleukin-4 receptor, and interleukin-18 polymorphisms and rheumatoid arthritis: a meta-analysis
- Authors
- Song, Gwan Gyu; Bae, Sang-Cheol; Kim, Jae-Hoon; Lee, Young Ho
- Issue Date
- 2013
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- interleukin-4; IL-18; polymorphism; rheumatoid arthritis; meta-analysis
- Citation
- IMMUNOLOGICAL INVESTIGATIONS, v.42, no.6, pp.455 - 469
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNOLOGICAL INVESTIGATIONS
- Volume
- 42
- Number
- 6
- Start Page
- 455
- End Page
- 469
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106421
- DOI
- 10.3109/08820139.2013.804084
- ISSN
- 0882-0139
- Abstract
- Objective: The aim of this study was to determine whether the functional interleukin-4 (IL-4) -590 C/T, IL-4 receptor (IL-4R) 1902 G/A, IL-18 -607 C/A, and -137 G/C polymorphisms polymorphisms confer susceptibility to rheumatoid arthritis (RA). Methods: Meta-analysis was conducted on the associations between these IL-4, IL-4R, and IL-18 polymorphisms and RA. Results: A total of 12 comparative studies were included in this meta-analysis. Meta-analysis of the IL-4 -590 C/T polymorphism showed an association in all study subjects and Europeans (OR for the TT genotype = 2.280, 95% CI = 1.315-3.952, p = 0.003; OR = 2.139, 95% CI = 1.089-4.199, p = 0.027). However, meta-analysis showed no association between RA and the IL-4R 1902 G allele in all study subjects and Europeans. Meta-analysis showed no association between RA and the IL-18 -607 C allele (OR = 1.159, 95% CI = 0.967-1.387, p = 0.110). Meta-analysis of the IL-18 -137 G/C polymorphism revealed no association between RA and the IL-18 -137 G/C polymorphism. Conclusions: This meta-analysis demonstrates that the IL-4 -590 T/C polymorphism is associated with susceptibility to RA in Europeans, but the IL-4R+1902 G/A, IL-18 -607 C/A and -137 G/C polymorphisms are not associated with RA.
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