Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD
DC Field | Value | Language |
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dc.contributor.author | Kim, Changhwan | - |
dc.contributor.author | Seo, Joon Beom | - |
dc.contributor.author | Lee, Sang Min | - |
dc.contributor.author | Lee, Jae Seung | - |
dc.contributor.author | Huh, Jin Won | - |
dc.contributor.author | Lee, Jin Hwa | - |
dc.contributor.author | Ra, Seung Won | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Kim, Eun-Kyung | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Kim, Woo Jin | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Lim, Seong Yong | - |
dc.contributor.author | Shin, Tae Rim | - |
dc.contributor.author | Yoon, Ho Il | - |
dc.contributor.author | Sheen, Seung Soo | - |
dc.contributor.author | Oh, Yeon-Mok | - |
dc.contributor.author | Park, Yong Bum | - |
dc.contributor.author | Lee, Sang-Do | - |
dc.date.accessioned | 2021-09-06T11:28:46Z | - |
dc.date.available | 2021-09-06T11:28:46Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106510 | - |
dc.description.abstract | Background: To date, no clinical parameter has been associated with the decline in lung function other than emphysema severity in COPD. Objectives: The main purpose of this study was to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation. Methods: A total of 224 subjects were selected from the Korean Obstructive Lung Disease cohort. Exertional desaturation was assessed using the 6-min walk test (6MWT), and defined as a post-exercise oxygen saturation (SpO(2)) of <90% or a >= 4% decrease. The cohort was divided into desaturator (n = 47) and non-desaturator (n = 177) groups. Results: There was a significant difference between the desaturator and non-desaturator groups in terms of the change in pre-bronchodilator forced expiratory volume in 1 s (FEV1) over a 3-year period of follow-up (p = 0.006). The mean rate of decline in FEV1 was greater in the desaturator group (33.8 ml/year) than in the non-desaturator group (11.6 ml/year). A statistically significant difference was also observed between the two groups in terms of the change in the St. George's Respiratory Questionnaire (SGRQ) total score over 3 years (p = 0.001). Conclusions: This study suggests, for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD. Copyright (c) 2012 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | BREATH DIFFUSING-CAPACITY | - |
dc.subject | 6-MIN WALK TEST | - |
dc.subject | OXYGEN DESATURATION | - |
dc.subject | COMPUTED DENSITY | - |
dc.subject | EXERCISE | - |
dc.subject | EMPHYSEMA | - |
dc.subject | DISTANCE | - |
dc.subject | TIME | - |
dc.subject | MORPHOMETRY | - |
dc.subject | PROGNOSIS | - |
dc.title | Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeub | - |
dc.identifier.doi | 10.1159/000342891 | - |
dc.identifier.scopusid | 2-s2.0-84883184842 | - |
dc.identifier.wosid | 000324693200003 | - |
dc.identifier.bibliographicCitation | RESPIRATION, v.86, no.2, pp.109 - 116 | - |
dc.relation.isPartOf | RESPIRATION | - |
dc.citation.title | RESPIRATION | - |
dc.citation.volume | 86 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 109 | - |
dc.citation.endPage | 116 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | BREATH DIFFUSING-CAPACITY | - |
dc.subject.keywordPlus | 6-MIN WALK TEST | - |
dc.subject.keywordPlus | OXYGEN DESATURATION | - |
dc.subject.keywordPlus | COMPUTED DENSITY | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | EMPHYSEMA | - |
dc.subject.keywordPlus | DISTANCE | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordPlus | MORPHOMETRY | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordAuthor | Chronic obstructive pulmonary disease | - |
dc.subject.keywordAuthor | Computed tomography | - |
dc.subject.keywordAuthor | Emphysema | - |
dc.subject.keywordAuthor | Exertional desaturation | - |
dc.subject.keywordAuthor | Lung function | - |
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