Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD
- Authors
- Kim, Changhwan; Seo, Joon Beom; Lee, Sang Min; Lee, Jae Seung; Huh, Jin Won; Lee, Jin Hwa; Ra, Seung Won; Lee, Ji-Hyun; Kim, Eun-Kyung; Kim, Tae-Hyung; Kim, Woo Jin; Lee, Sang-Min; Lee, Sang Yeub; Lim, Seong Yong; Shin, Tae Rim; Yoon, Ho Il; Sheen, Seung Soo; Oh, Yeon-Mok; Park, Yong Bum; Lee, Sang-Do
- Issue Date
- 2013
- Publisher
- KARGER
- Keywords
- Chronic obstructive pulmonary disease; Computed tomography; Emphysema; Exertional desaturation; Lung function
- Citation
- RESPIRATION, v.86, no.2, pp.109 - 116
- Indexed
- SCIE
SCOPUS
- Journal Title
- RESPIRATION
- Volume
- 86
- Number
- 2
- Start Page
- 109
- End Page
- 116
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106510
- DOI
- 10.1159/000342891
- ISSN
- 0025-7931
- Abstract
- Background: To date, no clinical parameter has been associated with the decline in lung function other than emphysema severity in COPD. Objectives: The main purpose of this study was to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation. Methods: A total of 224 subjects were selected from the Korean Obstructive Lung Disease cohort. Exertional desaturation was assessed using the 6-min walk test (6MWT), and defined as a post-exercise oxygen saturation (SpO(2)) of <90% or a >= 4% decrease. The cohort was divided into desaturator (n = 47) and non-desaturator (n = 177) groups. Results: There was a significant difference between the desaturator and non-desaturator groups in terms of the change in pre-bronchodilator forced expiratory volume in 1 s (FEV1) over a 3-year period of follow-up (p = 0.006). The mean rate of decline in FEV1 was greater in the desaturator group (33.8 ml/year) than in the non-desaturator group (11.6 ml/year). A statistically significant difference was also observed between the two groups in terms of the change in the St. George's Respiratory Questionnaire (SGRQ) total score over 3 years (p = 0.001). Conclusions: This study suggests, for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD. Copyright (c) 2012 S. Karger AG, Basel
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