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Rapid Determination of Volatile Organic Compounds in Human Whole Blood Using Static Headspace Sampling with Gas Chromatography and Mass Spectrometry
- Issue Date
- 20-Dec-2012
- Publisher
- KOREAN CHEMICAL SOC
- Keywords
- VOCs; Whole blood; Headspace; HS-GC-MS
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.12, pp.3963 - 3970
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 33
- Number
- 12
- Start Page
- 3963
- End Page
- 3970
- ISSN
- 0253-2964
- Abstract
- Headspace (HS) and headspace solid-phase microextraction (HS-SPME) were studied for extracting volatile organic compounds (VOCs) from whole blood, with chemical and instrumental variables being optimized for maximum sensitivity: incubation at 60 degrees C, equilibration for 30 mm, pH 11, and 2 mL injection volume. Both techniques provided accurate analyses, with detection limits of 0.05-0.1 ng mL(-1) and 0.05-0.5 ng mL(-1). HS showed better sensitivity, reproducibility, and analysis times than HS-SPME. Overall levels of chloroform in whole blood were found to be 0.05-5.84 ng mL(-1); detected levels of benzene were 0.05-2.20 ng mL(-1).
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Collections - Graduate School > Department of Public Health Sciences > 1. Journal Articles
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Related Researcher
- Lee, Jong Tae
- Department of Public Health Sciences