BRYOSTATIN-1 PROMOTES LONG-TERM POTENTIATION VIA ACTIVATION OF PKC alpha AND PKC epsilon IN THE HIPPOCAMPUS
DC Field | Value | Language |
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dc.contributor.author | Kim, H. | - |
dc.contributor.author | Han, S. H. | - |
dc.contributor.author | Quan, H. Y. | - |
dc.contributor.author | Jung, Y-J | - |
dc.contributor.author | An, J. | - |
dc.contributor.author | Kang, P. | - |
dc.contributor.author | Park, J. -B. | - |
dc.contributor.author | Yoon, B. -J. | - |
dc.contributor.author | Seol, G. H. | - |
dc.contributor.author | Min, S. S. | - |
dc.date.accessioned | 2021-09-06T11:58:11Z | - |
dc.date.available | 2021-09-06T11:58:11Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12-13 | - |
dc.identifier.issn | 0306-4522 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106660 | - |
dc.description.abstract | Activation of protein kinase C (PKC) by bryostatin-1 affects various functions of the central nervous system. We explored whether bryostatin-1 influenced synaptic plasticity via a process involving PKC. Our purpose was to examine whether bryostatin-1 affected the induction of hippocampal long-term potentiation (LTP) in Schaffer-collateral fibers (CA1 fibers) of the hippocampus, and/or influenced the intracellular Ca2+ level of hippocampal neurons. We also determined the PKC isoforms involved in these processes. We found that bryostatin-1 strongly facilitated LTP induction, in a dose-dependent manner, upon single-theta burst stimulation (TBS). Further, intracellular Ca2+ levels also increased with increasing concentration of bryostatin-1. The facilitative effects of bryostatin-1 in terms of LTP induction and enhancement of intracellular Ca2+ levels were blocked by specific inhibitors of PKCa and PKCE, but not of PKGS. Our results suggest that bryostatin-1 is involved in neuronal functioning and facilitates induction of LTP via activation of PKC alpha and/or PKCE. (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | PHORBOL 12-MYRISTATE 13-ACETATE | - |
dc.subject | SYNAPTIC PLASTICITY | - |
dc.subject | SPATIAL MEMORY | - |
dc.subject | RECEPTOR TRAFFICKING | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | PROSTATE-CANCER | - |
dc.subject | NMDA RECEPTORS | - |
dc.subject | ENHANCEMENT | - |
dc.subject | ISOZYMES | - |
dc.title | BRYOSTATIN-1 PROMOTES LONG-TERM POTENTIATION VIA ACTIVATION OF PKC alpha AND PKC epsilon IN THE HIPPOCAMPUS | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, B. -J. | - |
dc.contributor.affiliatedAuthor | Seol, G. H. | - |
dc.identifier.doi | 10.1016/j.neuroscience.2012.08.055 | - |
dc.identifier.scopusid | 2-s2.0-84867416223 | - |
dc.identifier.wosid | 000311865100029 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE, v.226, pp.348 - 355 | - |
dc.relation.isPartOf | NEUROSCIENCE | - |
dc.citation.title | NEUROSCIENCE | - |
dc.citation.volume | 226 | - |
dc.citation.startPage | 348 | - |
dc.citation.endPage | 355 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | PHORBOL 12-MYRISTATE 13-ACETATE | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | SPATIAL MEMORY | - |
dc.subject.keywordPlus | RECEPTOR TRAFFICKING | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | NMDA RECEPTORS | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | ISOZYMES | - |
dc.subject.keywordAuthor | bryostatin-1 | - |
dc.subject.keywordAuthor | long-term potentiation (LTP) | - |
dc.subject.keywordAuthor | synaptic plasticity | - |
dc.subject.keywordAuthor | protein kinase C (PKC) | - |
dc.subject.keywordAuthor | hippocampus | - |
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