BRYOSTATIN-1 PROMOTES LONG-TERM POTENTIATION VIA ACTIVATION OF PKC alpha AND PKC epsilon IN THE HIPPOCAMPUS
- Authors
- Kim, H.; Han, S. H.; Quan, H. Y.; Jung, Y-J; An, J.; Kang, P.; Park, J. -B.; Yoon, B. -J.; Seol, G. H.; Min, S. S.
- Issue Date
- 13-12월-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- bryostatin-1; long-term potentiation (LTP); synaptic plasticity; protein kinase C (PKC); hippocampus
- Citation
- NEUROSCIENCE, v.226, pp.348 - 355
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROSCIENCE
- Volume
- 226
- Start Page
- 348
- End Page
- 355
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106660
- DOI
- 10.1016/j.neuroscience.2012.08.055
- ISSN
- 0306-4522
- Abstract
- Activation of protein kinase C (PKC) by bryostatin-1 affects various functions of the central nervous system. We explored whether bryostatin-1 influenced synaptic plasticity via a process involving PKC. Our purpose was to examine whether bryostatin-1 affected the induction of hippocampal long-term potentiation (LTP) in Schaffer-collateral fibers (CA1 fibers) of the hippocampus, and/or influenced the intracellular Ca2+ level of hippocampal neurons. We also determined the PKC isoforms involved in these processes. We found that bryostatin-1 strongly facilitated LTP induction, in a dose-dependent manner, upon single-theta burst stimulation (TBS). Further, intracellular Ca2+ levels also increased with increasing concentration of bryostatin-1. The facilitative effects of bryostatin-1 in terms of LTP induction and enhancement of intracellular Ca2+ levels were blocked by specific inhibitors of PKCa and PKCE, but not of PKGS. Our results suggest that bryostatin-1 is involved in neuronal functioning and facilitates induction of LTP via activation of PKC alpha and/or PKCE. (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
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