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A Coumarin-based Fluorescence Sensor for the Reversible Detection of Thiols

Authors
Cho, A. YoungChoi, Kihang
Issue Date
5-12월-2012
Publisher
CHEMICAL SOC JAPAN
Citation
CHEMISTRY LETTERS, v.41, no.12, pp.1611 - 1612
Indexed
SCIE
SCOPUS
Journal Title
CHEMISTRY LETTERS
Volume
41
Number
12
Start Page
1611
End Page
1612
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106683
DOI
10.1246/cl.2012.1611
ISSN
0366-7022
Abstract
A coumarin derivative with a cyanoacrylamide electrophile was prepared and used for fluorescence sensing of thiols. Thiol addition to the electrophile proceeded in a reversible manner so that the compound displayed fluorescence emission depending on thiol concentrations. Dissociation constants of the thiol addition products are in the mM ranges, which are similar to cellular thiol concentrations.
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