Generation and evaluation of the efficacy of rhesus monkey soluble cytotoxic T lymphocyte-associated antigen-4 in the allogeneic mixed lymphocyte reaction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jung-Sik | - |
dc.contributor.author | Choi, Inho | - |
dc.contributor.author | Lee, Han-Hyoung | - |
dc.contributor.author | Lee, Suk Jun | - |
dc.contributor.author | Na, Manheum | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Han, Jihye | - |
dc.contributor.author | Bae, Joonbeom | - |
dc.contributor.author | Choi, Sang-Pil | - |
dc.contributor.author | Kim, Sang Joon | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Chun, Taehoon | - |
dc.date.accessioned | 2021-09-06T12:20:38Z | - |
dc.date.available | 2021-09-06T12:20:38Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106730 | - |
dc.description.abstract | Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4; CD152) is a transmembrane protein that is structurally similar to CD28. As CTLA-4 has a much higher binding affinity to B7 than CD28, several approaches using soluble CTLA-4 have been tried to down-regulate T cell activity by blocking the interaction between CD28 and B7. We constructed soluble rhesus monkey CTLA-4 immunoglobulin (CTLA-4Ig) containing a critical binding site to B7 combined with a constant Ig heavy chain region in a mammalian system. Flow cytometry analyses indicated that soluble rhesus monkey CTLA-4Ig bound to rhesus monkey CD86 (B7.2). Moreover, soluble rhesus monkey CTLA-4Ig more effectively blocked the rhesus monkey-rhesus monkey allogeneic mixed lymphocyte reaction compared with that of humans. These results indicate that soluble rhesus monkey CTLA-4Ig may be useful in preclinical trials in a rhesus monkey model. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | CELL RESPONSES | - |
dc.subject | CTLA-4 | - |
dc.subject | BELATACEPT | - |
dc.subject | MODELS | - |
dc.subject | PIG | - |
dc.title | Generation and evaluation of the efficacy of rhesus monkey soluble cytotoxic T lymphocyte-associated antigen-4 in the allogeneic mixed lymphocyte reaction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, Taehoon | - |
dc.identifier.doi | 10.1007/s10529-012-1026-0 | - |
dc.identifier.scopusid | 2-s2.0-84868382732 | - |
dc.identifier.wosid | 000310587500006 | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY LETTERS, v.34, no.12, pp.2191 - 2197 | - |
dc.relation.isPartOf | BIOTECHNOLOGY LETTERS | - |
dc.citation.title | BIOTECHNOLOGY LETTERS | - |
dc.citation.volume | 34 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2191 | - |
dc.citation.endPage | 2197 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | CELL RESPONSES | - |
dc.subject.keywordPlus | CTLA-4 | - |
dc.subject.keywordPlus | BELATACEPT | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | PIG | - |
dc.subject.keywordAuthor | Allogeneic response | - |
dc.subject.keywordAuthor | Co-stimulatory molecule | - |
dc.subject.keywordAuthor | Cytotoxic T lymphocyte-associated antigen-4 | - |
dc.subject.keywordAuthor | Mixed lymphocyte reaction | - |
dc.subject.keywordAuthor | Rhesus monkey | - |
dc.subject.keywordAuthor | T cells | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.