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Generation and evaluation of the efficacy of rhesus monkey soluble cytotoxic T lymphocyte-associated antigen-4 in the allogeneic mixed lymphocyte reaction

Authors
Kim, Jung-SikChoi, InhoLee, Han-HyoungLee, Suk JunNa, ManheumKim, Sang-HoonHan, JihyeBae, JoonbeomChoi, Sang-PilKim, Sang JoonPark, Chung-GyuChun, Taehoon
Issue Date
12월-2012
Publisher
SPRINGER
Keywords
Allogeneic response; Co-stimulatory molecule; Cytotoxic T lymphocyte-associated antigen-4; Mixed lymphocyte reaction; Rhesus monkey; T cells
Citation
BIOTECHNOLOGY LETTERS, v.34, no.12, pp.2191 - 2197
Indexed
SCIE
SCOPUS
Journal Title
BIOTECHNOLOGY LETTERS
Volume
34
Number
12
Start Page
2191
End Page
2197
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106730
DOI
10.1007/s10529-012-1026-0
ISSN
0141-5492
Abstract
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4; CD152) is a transmembrane protein that is structurally similar to CD28. As CTLA-4 has a much higher binding affinity to B7 than CD28, several approaches using soluble CTLA-4 have been tried to down-regulate T cell activity by blocking the interaction between CD28 and B7. We constructed soluble rhesus monkey CTLA-4 immunoglobulin (CTLA-4Ig) containing a critical binding site to B7 combined with a constant Ig heavy chain region in a mammalian system. Flow cytometry analyses indicated that soluble rhesus monkey CTLA-4Ig bound to rhesus monkey CD86 (B7.2). Moreover, soluble rhesus monkey CTLA-4Ig more effectively blocked the rhesus monkey-rhesus monkey allogeneic mixed lymphocyte reaction compared with that of humans. These results indicate that soluble rhesus monkey CTLA-4Ig may be useful in preclinical trials in a rhesus monkey model.
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