Astaxanthin production by a highly photosensitive Haematococcus mutant
- Authors
- Hong, Min-Eui; Choi, Seung Phill; Park, Youn-Il; Kim, Young-Kee; Chang, Won Seok; Kim, Byung Woo; Sim, Sang Jun
- Issue Date
- 12월-2012
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Haematococcus pluvialis; Astaxanthin; Photo-inducible mutant; Photo-sensitivity
- Citation
- PROCESS BIOCHEMISTRY, v.47, no.12, pp.1972 - 1979
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROCESS BIOCHEMISTRY
- Volume
- 47
- Number
- 12
- Start Page
- 1972
- End Page
- 1979
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106737
- DOI
- 10.1016/j.procbio.2012.07.007
- ISSN
- 1359-5113
- Abstract
- Haematococcus pluvialis synthesizes a high yield of astaxanthin using CO2 in a photoautotrophic culture without contaminant heterotrophs; however, it takes too long to induce astaxanthin production. In this study, a highly photosensitive mutant strain was attained by conventional random mutagenesis and an efficient isolation method to shorten induction time. Sensitivity to photoinhibition in this mutant was raised by a partial lesion in the photosystem II (PSII) of photosynthesis, thereby prompting a change in cellular morphology as well as stimulating carotenogenesis (astaxanthin production). As a result, the concentrations of cell biomass and astaxanthin were dramatically increased by 27% and 62% under strong light and 79% and 153% under moderate light, respectively. This Haematococcus mutant would be useful for the economical astaxanthin production capable of reducing the light energy cost in a photoautotrophic culture system, even in areas with insufficient sunlight. (C) 2012 Elsevier Ltd. All rights reserved.
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