Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-06T12:22:44Z | - |
dc.date.available | 2021-09-06T12:22:44Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 0770-3198 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106742 | - |
dc.description.abstract | The aim of this study was to summarize published results on the association between vitamin D intake and the development of rheumatoid arthritis (RA) and between serum vitamin D levels and RA activity. Evidence of a relationship between vitamin D intake and the development of RA and between serum vitamin D levels and RA activity was studied by summarizing published results using a meta-analysis approach. Three cohort studies including 215,757 participants and 874 incident cases of RA were considered in this meta-analysis, and eight studies on the association between serum vitamin D levels and RA activity involving 2,885 RA patients and 1,084 controls were included. Meta-analysis showed an association between total vitamin D intake and RA incidence (relative risk (RR) of the highest vs. the lowest group = 0.758, 95 % confidence interval (CI) 0.577-0.937, p = 0.047), without between-study heterogeneity (I (2) = 0 %, p = 0.595). Individuals in the highest group for total vitamin D intake were found to have a 24.2 % lower risk of developing RA than those in the lowest group. Subgroup meta-analysis also showed a significant association between vitamin D supplement intake and RA incidence (RR 0.764, 95 % CI 0.628-0.930, p = 0.007), without between-study heterogeneity. All studies, except for one, found that vitamin D levels are inversely associated with RA activity. One study found no correlation between vitamin D levels and disease activity among 85 RA patients, but these patients had a high incidence of vitamin D deficiency, which might have influenced the study outcome. Meta-analysis of 215,757 participants suggests that low vitamin D intake is associated with an elevated risk of RA development. Furthermore, available evidence indicates that vitamin D level is associated with RA activity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER LONDON LTD | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | DISEASE-ACTIVITY | - |
dc.subject | AUTOIMMUNE-DISEASE | - |
dc.subject | CLINICAL-TRIALS | - |
dc.subject | D DEFICIENCY | - |
dc.subject | PREVALENCE | - |
dc.subject | MECHANISMS | - |
dc.subject | DISABILITY | - |
dc.subject | WOMEN | - |
dc.title | Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s10067-012-2080-7 | - |
dc.identifier.scopusid | 2-s2.0-84872111058 | - |
dc.identifier.wosid | 000311510000013 | - |
dc.identifier.bibliographicCitation | CLINICAL RHEUMATOLOGY, v.31, no.12, pp.1733 - 1739 | - |
dc.relation.isPartOf | CLINICAL RHEUMATOLOGY | - |
dc.citation.title | CLINICAL RHEUMATOLOGY | - |
dc.citation.volume | 31 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1733 | - |
dc.citation.endPage | 1739 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASE | - |
dc.subject.keywordPlus | CLINICAL-TRIALS | - |
dc.subject.keywordPlus | D DEFICIENCY | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DISABILITY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordAuthor | Activity | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Susceptibility | - |
dc.subject.keywordAuthor | Vitamin D | - |
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