Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis
- Authors
- Song, Gwan Gyu; Bae, Sang-Cheol; Lee, Young Ho
- Issue Date
- 12월-2012
- Publisher
- SPRINGER LONDON LTD
- Keywords
- Activity; Rheumatoid arthritis; Susceptibility; Vitamin D
- Citation
- CLINICAL RHEUMATOLOGY, v.31, no.12, pp.1733 - 1739
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL RHEUMATOLOGY
- Volume
- 31
- Number
- 12
- Start Page
- 1733
- End Page
- 1739
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106742
- DOI
- 10.1007/s10067-012-2080-7
- ISSN
- 0770-3198
- Abstract
- The aim of this study was to summarize published results on the association between vitamin D intake and the development of rheumatoid arthritis (RA) and between serum vitamin D levels and RA activity. Evidence of a relationship between vitamin D intake and the development of RA and between serum vitamin D levels and RA activity was studied by summarizing published results using a meta-analysis approach. Three cohort studies including 215,757 participants and 874 incident cases of RA were considered in this meta-analysis, and eight studies on the association between serum vitamin D levels and RA activity involving 2,885 RA patients and 1,084 controls were included. Meta-analysis showed an association between total vitamin D intake and RA incidence (relative risk (RR) of the highest vs. the lowest group = 0.758, 95 % confidence interval (CI) 0.577-0.937, p = 0.047), without between-study heterogeneity (I (2) = 0 %, p = 0.595). Individuals in the highest group for total vitamin D intake were found to have a 24.2 % lower risk of developing RA than those in the lowest group. Subgroup meta-analysis also showed a significant association between vitamin D supplement intake and RA incidence (RR 0.764, 95 % CI 0.628-0.930, p = 0.007), without between-study heterogeneity. All studies, except for one, found that vitamin D levels are inversely associated with RA activity. One study found no correlation between vitamin D levels and disease activity among 85 RA patients, but these patients had a high incidence of vitamin D deficiency, which might have influenced the study outcome. Meta-analysis of 215,757 participants suggests that low vitamin D intake is associated with an elevated risk of RA development. Furthermore, available evidence indicates that vitamin D level is associated with RA activity.
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