Nanoencapsulation of Drug-loaded Lipid by Temperature-induced Phase Transition

Abstract

Pluronic nanoparticles (NPs) were prepared by means of a temperature-induced phase transition in the mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing model drugs such as orlistat, caffeine, and ibuprofen sodium salt. Liquid soybean oil/Tween 80 was used as a solubilizer for model drugs, and Pluronic F-68 was the polymer that stabilizes liquid soybean oil/Tween 80 containing model drugs. Field-emission scanning electron microscopy and particle size analyzer were used to observe the morphology and size distribution of the prepared NPs. X-ray diffractometer was used to understand relationship between the crystalline state of the model drug and its solubility in the aqueous media. To observe the feasibility of Pluronic NPs as a drug delivery system, the release pattern of model drugs was observed.