Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Green Tea Extract (Camellia sinensis) Fermented by Lactobacillus fermentum Attenuates Alcohol-Induced Liver Damage

Authors
Park, Jong HoKim, YounghoonKim, Sae Hun
Issue Date
12월-2012
Publisher
TAYLOR & FRANCIS LTD
Keywords
alcohol-induced liver damage; fermented green tea extract; Lactobacillus fermentum
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.76, no.12, pp.2294 - 2300
Indexed
SCIE
SCOPUS
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume
76
Number
12
Start Page
2294
End Page
2300
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106800
DOI
10.1271/bbb.120598
ISSN
0916-8451
Abstract
Here, the impact of an extract derived from green tea (Camellia sinensis) and fermentation with Lactobacilli fermentum strain OCS19 was explored with acute. alcohol-induced liver damage. The study employed the HepG2 hepatic cell line and an in vivo murine model of liver damage. L. fermentum-fermented green tea extract (FGTE) was found to possess pronounced alcohol metabolizing enzyme activity. It significantly enhanced the cell viability of HepG2 cells following of them exposure, to ethanol (p < 0.05) as compared with an extract derived from Hovenia dulcis, a positive control that is known for its action as an alcohol antagonist. Our in vivo studies indicated that prior administration of FGTE to alcohol-exposed mice significantly prevented subsequent increases in blood alcohol concentration (p < 0.05), in addition to the induction of serum alanine aminotransferase (ALT) and triglycerides (p < 0.05). Furthermore, the activity Of hepatic alcohol dehydrogenase (ADH) and its mRNA expression level both increased in the livers of mice treated with FGTE, similarly to the H. dulcis-treated group. Taken together, these results may suggest that green tea extract coupled with L. fermentum fermentation attenuates the risk of ethanol-induced liver damage.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Sae Hun photo

Kim, Sae Hun
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE