Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs
- Authors
- Huh, Jung-Bo; Kim, Sung-Eun; Kim, Hyo-Eon; Kang, Seong-Soo; Choi, Kyung-Hee; Jeong, Chang-Mo; Lee, Jeong-Yol; Shin, Sang-Wan
- Issue Date
- 12월-2012
- Publisher
- CHURCHILL LIVINGSTONE
- Keywords
- rhBMP-2; coating; anodized implant; osseointegration; bone growth
- Citation
- INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, v.41, no.12, pp.1577 - 1584
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
- Volume
- 41
- Number
- 12
- Start Page
- 1577
- End Page
- 1584
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106808
- DOI
- 10.1016/j.ijom.2012.04.005
- ISSN
- 0901-5027
- Abstract
- This study evaluated the effects of Escherichia con-derived rhBMP-2 (ErhBMP-2) coated onto anodized implants to stimulate bone formation, osseointegration and vertical bone growth in a vertical bone defect model. Six young adult beagle dogs were used. After a 2-month bone healing period, anodized titanium implants (8 mm in length) were placed 5.5 mm into the mandibular alveolar ridge. Eighteen implants coated with ErhBMP-2 (BM P group) and another 18 uncoated implants (control group) were installed using a randomized split-mouth design. The implant stability quotient (ISQ) values were measured. Specimens were fabricated for histometric analysis to evaluate osseointegration and bone formation. The ISQ values at 8 weeks after implant placement were significantly higher in the BMP group than in the control group (p < 0.05). Histological observations showed that the changes in bucco-lingual alveolar bone levels were higher in the BM P group than in the control group (p < 0.05). The ErhBMP-2 coated anodized implants can stimulate bone formation and increase implant stability significantly on completely healed alveolar ridges in dogs. Further studies evaluating the effects of ErhBMP-2 on osseointegration in the bone-implant interface are warranted.
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