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Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells
- Authors
- Jun, Hee-jin; Hoang, Minh-Hien; Lee, Jin Woo; Yaoyao, Jia; Lee, Ji-Hae; Lee, Dong-Ho; Lee, Hak-Ju; Seo, Woo-Duck; Hwang, Bang Yeon; Lee, Sung-Joon
- Issue Date
- 12월-2012
- Publisher
- SPRINGER
- Keywords
- Belamcanda chinensis; Cholesterol; Iristectorigenin B; LXR modulator
- Citation
- BIOTECHNOLOGY LETTERS, v.34, no.12, pp.2213 - 2221
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 34
- Number
- 12
- Start Page
- 2213
- End Page
- 2221
- ISSN
- 0141-5492
- Abstract
- A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-alpha and LXR-beta. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-alpha/-beta-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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