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Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy
- Authors
- Park, Yong Il; Kim, Hyung Min; Kim, Jeong Hyun; Moon, Kyung Chul; Yoo, Byeongjun; Lee, Kang Taek; Lee, Nohyun; Choi, Yoonseok; Park, Wooram; Ling, Daishun; Na, Kun; Moon, Woo Kyung; Choi, Seung Hong; Park, Hong Seok; Yoon, Soo-Young; Suh, Yung Doug; Lee, Sung Ho; Hyeon, Taeghwan
- Issue Date
- 8-11월-2012
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- luminescence; magnetic resonance imaging; nanoparticles; photodynamic therapy; upconversion
- Citation
- ADVANCED MATERIALS, v.24, no.42, pp.5755 - 5761
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED MATERIALS
- Volume
- 24
- Number
- 42
- Start Page
- 5755
- End Page
- 5761
- ISSN
- 0935-9648
- Abstract
- Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.
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