Inhibition of Biofilm Formation on Ventilation Tubes by Surface Modification
- Authors
- Song, Jae-Jun; Noh, Insup; Chae, Sung-Won
- Issue Date
- 11월-2012
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- Biofilm; ventilation tube; PEG coating; streptococcus pneumoniae R6
- Citation
- IN VIVO, v.26, no.6, pp.907 - 911
- Indexed
- SCIE
SCOPUS
- Journal Title
- IN VIVO
- Volume
- 26
- Number
- 6
- Start Page
- 907
- End Page
- 911
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107026
- ISSN
- 0258-851X
- Abstract
- Aim: The purpose of this study was to modify the surface characteristics of a ventilation tube (VT) with polyethylene glycol (PEG) coating and to evaluate the effect on biofilm formation. Materials and Methods: VTs made of polyethylene were coated with PEG. Streptococcus pneumonia R6 strain was used and a crystal violet assay was carried out to measure the in vitro and in vivo biofilm formation of rats bearing VTs. Results: In the in vitro experiment, the optical density of the uncoated VT was 0.34 +/- 0.09 and the optical density of the PEG-grafted VT was 0.22 +/- 0.06 (p<0.05). In the in vivo experiment, the optical density of the uncoated VT was 0.54 +/- 0.12 and that of the PEG-grafted VT was 0.32 +/- 0.13 (p<0.05). Scanning electron microscopy showed that surface modification, roughness and hydrophilic characteristics improved and biofilm formation decreased. Conclusion: The reduced biofilm formation on the VT may be explained by the alteration of surface tension and roughness induced by PEG coating.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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