Radiobiological model-based bio-anatomical quality assurance in intensity-modulated radiation therapy for prostate cancer
- Authors
- Park, Ji-Yeon; Lee, Jeong-Woo; Chung, Jin-Beom; Choi, Kyoung-Sik; Kim, Yon-Lae; Park, Byung-Moon; Kim, Youhyun; Kim, Jungmin; Choi, Jonghak; Kim, Jae-Sung; Hong, Semie; Suh, Tae-Suk
- Issue Date
- 11월-2012
- Publisher
- OXFORD UNIV PRESS
- Keywords
- Bio-anatomical quality assurance; tumor control probability; normal tissue complication probability; intensity-modulated radiation therapy; prostate cancer
- Citation
- JOURNAL OF RADIATION RESEARCH, v.53, no.6, pp.978 - 988
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF RADIATION RESEARCH
- Volume
- 53
- Number
- 6
- Start Page
- 978
- End Page
- 988
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107095
- DOI
- 10.1093/jrr/rrs049
- ISSN
- 0449-3060
- Abstract
- A bio-anatomical quality assurance (QA) method employing tumor control probability (TCP) and normal tissue complication probability (NTCP) is described that can integrate radiobiological effects into intensity-modulated radiation therapy (IMRT). We evaluated the variations in the radiobiological effects caused by random errors (r-errors) and systematic errors (s-errors) by evaluating TCP and NTCP in two groups: patients with an intact prostate (G(intact)) and those who have undergone prostatectomy (G(tectomy)). The r-errors were generated using an isocenter shift of +/- 1 mm to simulate a misaligned patient set-up. The s-errors were generated using individual leaves that were displaced inwardly and outwardly by 1 mm on multileaf collimator field files. Subvolume-based TCP and NTCP were visualized on computed tomography (CT) images to determine the radiobiological effects on the principal structures. The bio-anatomical QA using the TCP and NTCP maps differentiated the critical radiobiological effects on specific volumes, particularly at the anterior rectal walls and planning target volumes. The s-errors showed a TCP variation of -40-25% in Gtectomy and -30-10% in Gintact, while the r-errors were less than 1.5% in both groups. The r-errors for the rectum and bladder showed higher NTCP variations at +/- 20% and +/- 10%, respectively, and the s-errors were greater than +/- 65% for both. This bio-anatomical method, as a patient-specific IMRT QA, can provide distinct indications of clinically significant radiobiological effects beyond the minimization of probable physical dose errors in phantoms.
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Collections - College of Health Sciences > School of Health and Environmental Science > 1. Journal Articles
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