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Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia

Authors
Kim, HawkLee, Kyoo-HyungYoon, Sung-SooSohn, Sang KyunJoo, Young DonKim, Sung HyunKim, Byung SooChoi, Jung HyeKwak, Jae YougHyun, Myung SooBae, Sung HwaShin, Ho JinWon, Jong HoOh, SukjoongLee, Won SikPark, Jae-HooJung, Chul Won
Issue Date
10월-2012
Publisher
ELSEVIER SCIENCE INC
Keywords
Aplastic anemia; Allogeneic hematopoietic stem cell transplantation; Elderly
Citation
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, v.18, no.10, pp.1500 - 1508
Indexed
SCIE
SCOPUS
Journal Title
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume
18
Number
10
Start Page
1500
End Page
1508
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/107253
DOI
10.1016/j.bbmt.2012.03.015
ISSN
1083-8791
Abstract
Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age. We retrospectively analyzed the impact of older age on transplantation outcomes and survival in a total of 225 adult patients with AA who underwent allo-HSCT: 57 patients >40 years old (older patient group [OPG]) and 168 patients <= 40 years old (younger patient group [YPG]). Age at allo-HSCT <= 40 years, time from diagnosis to allo-HSCT <= 6 months, and matched related donor (MRD) were favorable prognostic factors in all study patients. Risk analysis of survival in the OPG showed that age >50 years was the only poor prognostic factor. Survival did not differ significantly between the YPG and patients <50 years old in the OPG. In conclusion, patients between the ages of 41 and 50 years with severe AA and MRDs should undergo allo-HSCT as early as possible to optimize survival. Biol Blood Marrow Transplant 18: 1500-1508 (2012) (C) 2012 American Society fir Blood and Marrow Transplantation
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